Association between Lower Normal Free Thyroxine Concentrations and Obesity Phenotype in Healthy Euthyroid Subjects
Table 4
Adjusted odd ratios (ORs) and 95% confidence intervals (CIs) for insulin resistance according to FT4 quartiles.
Quartile of FT4 levels (mg/dL)
Q1
Q2
Q3
Q4
for trend
Total
1602
1458
1626
1555
Model 1
2.17 (1.84–2.57)
1.62 (1.37–1.93)
1.33 (1.12–1.58)
1 (Ref)
<0.001
Model 2
1.99 (1.65–2.40)
1.54 (1.27–1.87)
1.21 (1.00–1.47)
1 (Ref)
<0.001
Model 3
1.99 (1.61–2.46)
1.54 (1.24–1.93)
1.26 (1.01–1.57)
1 (Ref)
<0.001
NW
970
945
1110
1106
Model 1
1.76 (1.37–2.26)
1.46 (1.13–1.89)
1.30 (1.01–1.68)
1 (Ref)
0.001
Model 2
1.85 (1.43–2.40)
1.48 (1.13–1.94)
1.21 (0.93–1.57)
1 (Ref)
<0.001
Model 3
1.76 (1.31–2.38)
1.48 (1.08–2.02)
1.27 (0.94–1.73)
1 (Ref)
0.002
OW/OB
632
513
516
449
Model 1
2.23 (1.74–2.87)
1.60 (1.24–2.08)
1.30 (1.00–1.69)
1 (Ref)
<0.001
Model 2
2.13 (1.62–2.79)
1.60 (1.21–2.12)
1.21 (0.92–1.61)
1 (Ref)
<0.001
Model 3
2.19 (1.62–2.96)
1.60 (1.17–2.20)
1.23 (0.90–1.68)
1 (Ref)
<0.001
Model 1: adjusted for age and sex. Model 2: adjusted for age, sex, BMI, WC, heart rate, hypertension, and hyperlipidemia. Model 3: adjusted for age, sex, BMI, WC, heart rate, hypertension, hyperlipidemia, regular exercise, and smoking (total, ; NW, ; OW/OB, ).
