Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings

Table 1

Baseline characteristics of study participants.

Parameter	Placebo	Leptin	𝑃 value*
Age (y)	42.2 ± 2.8	51.4 ± 2.0	0.02
Pre-RYGB BMI (kg/m^2)	48.6 ± 1.9	47.1 ± 1.8	0.58
BMI at screen (kg/m^2)	35.0 ± 1.1	33.3 ± 1.4	0.35
Wt Loss (%)	30.2 ± 2.3	30.7 ± 2.1	0.88
Post-op period (mo)	44.2 ± 7.4	64.6 ± 8.6	0.09
Leptin (ng/mL)	27.1 ± 3.2	21.8 ± 2.5	0.20
Leptin/kg FM (ng/mL/kg)	0.70 ± 0.06^a	0.66 ± 0.06^b	0.61

Results are expressed as mean ± SEM. 𝑛=11 subjects per group except as follows: ^a𝑛=9; ^b𝑛=10. ^∗𝑃 value obtained by two-tailed independent 𝑡-test.