Recombinant Human Leptin Does Not Alter Gut Hormone Levels after Gastric Bypass but May Attenuate Sweet Cravings
Table 2
Changes in weight, glucostatic, and appetitive hormones.
Placebo
Leptin
Week 0
Week 16
Week 0
Week 16
Wt (kg)
91.5 ± 4.9
91.1 ± 5.1
86.2 ± 3.8
86.4 ± 3.9
0.74
Leptin (ng/mL)
27.1 ± 3.2
29.8 ± 4.5
21.8 ± 2.5
223.4 ± 66ab
0.01
Glucose (mg/dL)
86.2 ± 1.8
84.4 ± 2.5
88.0 ± 1.7
88.0 ± 2.1
0.49
Insulin (IU/mL)
3.0 ± 0.4
3.6 ± 0.6
4.2 ± 0.7
4.1 ± 0.8
0.34
Glucose AUC
10354 ± 599
11506 ± 294
11718 ± 338b
11814 ± 438
0.20
Insulin AUC
2990 ± 327
4693 ± 888a
4553 ± 455
4181 ± 561
0.04
HOMA-IR
0.63 ± 0.08
0.76 ± 0.13
0.90 ± 0.14
0.89 ± 0.19
0.40
CPEP (ng/mL)
1.31 ± 0.11
1.30 ± 0.15
1.42 ± 0.14
1.40 ± 0.17
0.94
CPEP AUC
8.5 ± 0.7
10.3 ± 1.4
10.9 ± 1.3
9.8 ± 1.2
0.07
GLP-1 (pg/mL)
11.5 ± 2.1
9.7 ± 2.2
6.8 ± 1.6
7.1 ± 1.4
0.54
GLP-1 AUC
1332 ± 166
1136 ± 84
1957 ± 395
1171 ± 198a
0.21
PYY (pg/mL)
69.1 ± 12.6
43.0 ± 10.6a
47.9 ± 10.4
58.5 ± 15.6
0.04
PYY AUC
19536 ± 2483
16968 ± 2793
19557 ± 3405
21619 ± 3380
0.15
Glucagon (pg/mL)
79 ± 7
75 ± 7
71 ± 7
82 ± 5
0.10
Glucagon AUC
197 ± 20
231 ± 20a
216 ± 15
251 ± 10a
0.96
Ghrelin (pg/mL)
379 ± 54
379 ± 53
343 ± 48
326 ± 43
0.42
Acyl-ghrelin (pg/mL)
34.1 ± 13.5
31.7 ± 9.9
18.8 ± 5.4
21.9 ± 4.4
0.59
Desacyl-ghrelin (pg/mL)
64.7 ± 16.3
68.4 ± 19.0
41.4 ± 0.4
37.2 ± 3.2
0.63
Results are expressed as mean ± SEM. subjects per group except for ghrelin, acyl-ghrelin, and desacyl-ghrelin, where for placebo group. Hormone measurements are from the fasted state unless otherwise indicated. ; week 16 is statistically different from week 0 within group. ; difference in values is statistically significant between groups at the same week. ; statistically significant values for group by time interaction.
