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International Journal of Endocrinology
Volume 2014, Article ID 134575, 10 pages
Research Article

Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats

1Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 112, Taiwan
2Division of Cardiovascular Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei 112, Taiwan
3Nursing Department, Cheng Kung University Hospital, Tainan 701, Taiwan
4Department of Nursing, Chang Jung Christian University, Tainan 712, Taiwan
5Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan
6Department of Surgery, Chi Mei Medical Center, Tainan 710, Taiwan
7Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan 712, Taiwan

Received 17 September 2013; Revised 22 November 2013; Accepted 1 January 2014; Published 17 February 2014

Academic Editor: Ashutosh Kumar

Copyright © 2014 Chuan-Chih Hsu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We aimed at investigating the effect of honokiol on heatstroke in an experimental rat model. Sprogue-Dawley rats were divided into 3 groups: normothermic diabetic rats treated with vehicle solution (NTDR+V), heatstroke-diabetic rats treated with vehicle (HSDR+V), and heatstroke rats treated with konokiol (0.5–5 mg/ml/kg) (HSDR+H). Sixty minutes before the start of heat stress, honokiol or vehicle solution was administered. (HSDR+H) significantly (a) attenuated hyperthermia, hypotension and hypothalamic ischemia, hypoxia, and neuronal apoptosis; (b) reduced the plasma index of the toxic oxidizing radicals; (c) diminished the indices of hepatic and renal dysfunction; (d) attenuated the plasma systemic inflammatory response molecules; (e) promoted plasma levels of an anti-inflammatory cytokine; (f) reduced the index of infiltration of polymorphonuclear neutrophils in the serum; and (g) promoted the survival time fourfold compared with the (HSDR+V) group. In conclusion, honokiol protected against the outcome of heatstroke by reducing inflammation and oxidative stress-mediated multiple organ dysfunction in diabetic rats.