Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats

Table 3

The plasma levels of both adrenocorticotrophic-hormone (ACTH) and corticosterone for (NTDR + V) rats, (HSDR + V) rats, and (HSDR + H) rats.

Treatment groups/time	ACTH (pg⋅mL^−1)	Corticosterone (ng⋅mL^−1)
(1) NTDR + V:
0 min	412±108 (8)	139±25 (8)
60 min	429±113 (8)	145±23 (8)
(2) HSDR + V:
0 min	407±99 (8)	128±21 (8)
60 min	1063±164^∗ (8)	428±23^∗ (8)
(3) HSDR + H:
0 min	421±120 (8)	133±24 (8)
60 min	1965±185^+ (8)	747±33^+ (8)

All heatstroke rats which had heat exposure (43°C) were withdrawn exactly at 60 minutes and then allowed to recover at room temperature (26°C). Data are man ± SD, followed by number of animals in parentheses.
 ^∗𝑃<0.05, in comparison with Group 1.
 ⁺𝑃<0.05, in comparison with Group 2 (Dunn’s test followed by Kruskal-Wallis test); vehicle solution (V) or honokiol (H) was adopted 60 min before the start of heat exposure.