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International Journal of Endocrinology
Volume 2014, Article ID 142468, 6 pages
http://dx.doi.org/10.1155/2014/142468
Research Article

The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1–5 Chronic Kidney Disease

1Department of Endocrinology and Nutrition, University Hospital of Amiens, 80054 Amiens, France
2INSERM Unit 1088, Jules Verne University of Picardie, 80037 Amiens, France
3Bone Biology and Endocrine Division, University Hospital of Amiens, 80054 Amiens, France
4Clinical Research Center, University Hospital of Amiens, 80054 Amiens, France
5Department of Clinical Nephrology, University Hospital of Amiens, 80054 Amiens, France

Received 28 May 2014; Revised 18 July 2014; Accepted 14 August 2014; Published 27 August 2014

Academic Editor: Andreas Tomaschitz

Copyright © 2014 Farshad Kajbaf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To examine the relationship between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood hemoglobin A1c (HbA1c) levels in diabetic patients at various stages of chronic kidney disease (CKD). Methods. We screened for data collected between 2003 and 2012. The correlation between 25(OH)D and HbA1c levels was studied in patients categorized according to the severity of CKD and their vitamin D status. A multivariate linear regression model was used to determine whether 25(OH)D and HbA1c levels were independently associated after adjustment for a number of covariates (including erythrocyte metformin levels). Results. We identified 542 reports from 245 patients. The mean HbA1c value was % in vitamin D sufficiency, % in insufficiency, and % in deficiency (). There was a negative correlation between 25(OH)D and HbA1c levels for the population as a whole (, ) and in the CKD severity subgroups (, and , for CKD stages 1–3 and 4-5, resp.). In the multivariate analysis, the 25(OH)D level was the only factor associated with HbA1c (). Conclusion. 25(OH)D levels were negatively correlated with HbA1c levels independently of study covariates.