Table 2: Association between testosterone level and severity of coronary artery disease.

Study nameSubfraction of testosterone used for analysisMethod of measuring CAD severityMain findingsRemarks

Dobrzycki et al. [34]  
(CCS, )
TT, FT, FAIDuke index*Inverse correlation between FT and CAD severity ,
Rosano et al. [35]  
(CCS, )
TTCoronary artery score**Inverse correlation between TT and CAD severity ,
Li et al. [36]  
(CCS, )
TTGenisi score***Inverse correlation between TT and CAD severity ,
Phillips et al. [37]  
(CCS, )
TT, FTVisual estimation of coronary artery occlusion and calculation of mean percent occlusion****Inverse correlation between TT and FT levels and CAD severityTT: , ;
FT: ,

CAD indicates coronary artery disease; CCS: case-control study; FAI: free androgen index; FT: free testosterone; TT: total testosterone.
Duke prognostic coronary artery index: a prognostic tool involving the extent and severity of atherosclerotic lesions in coronary arteries.
Coronary artery score: authors multiplied the degree of coronary artery obstruction by the number of stenoses.
Genisi score: calculated based on location and number of stenotic coronary artery segments, and degree of luminal narrowing.
Authors visually estimated the maximum percent reduction in luminal diameter of the left main, left anterior descending, left circumflex, and right coronary arteries. The mean of these 4 values was used to estimate CAD severity.