L-Arginine Supplementation in Type II Diabetic Rats Preserves Renal Function and Improves Insulin Sensitivity by Altering the Nitric Oxide Pathway

Table 1

Effect of high sucrose diet and L-Arginine supplementation on eNOS/𝛽-actin ratio in kidney cortex and medulla.

	Control		High sucrose diet		+L-arginine supplement
	Cortex	Medulla	Cortex	Medulla	Cortex	Medulla
𝑁	8	7	8	7	7	7
eNOS monomers/𝛽-actin	2.297±0.617	2.972±0.564	2.472±0.176	2.356±0.352	6.622±2.876	15.961±7.043^1,2
eNOS dimers/𝛽-actin	0.656±0.180	1.620±0.274^∗	0.065±0.045^1	0.023±0.023^1	0.138±0.090^1	0.205±0.205^1
eNOS total/𝛽-actin	2.953±0.777	4.593±0.825	2.537±0.189	2.379±0.357	6.759±2.965	16.167±7.170^1,2
Dimer/monomer ratio	0.348±0.057	0.599±0.071^∗	0.025±0.017^1	0.008±0.008^1	0.008±0.005^1	0.005±0.005^1

^∗𝑃<0.05 versus cortex, ¹𝑃<0.05 versus control, and ²𝑃<0.05 versus high sucrose diet.