L-Arginine Supplementation in Type II Diabetic Rats Preserves Renal Function and Improves Insulin Sensitivity by Altering the Nitric Oxide Pathway

Table 2

Effect of a high sucrose diet and L-arginine supplementation on iNOS/𝛽-actin ratio in the kidney cortex and medulla.

	Control		High sucrose diet		+L-arginine supplement
	Cortex	Medulla	Cortex	Medulla	Cortex	Medulla
𝑁	8	7	7	6	9	9
iNOS monomers/𝛽-actin	3.432±0.511	3.908±0.928	2.568±0.165	2.383±0.174^1	2.383±0.114	2.292±0.225^1
iNOS dimers/𝛽-actin	1.146±0.223	3.244±0.667^∗	0.105±0.071^1	0.419±0.262^1	0.011±0.007^1	0.042±0.040^1
iNOS total/𝛽-actin	4.578±0.654	7.151±1.540^∗	2.673±0.221	2.802±0.396^1	2.395±0.118^1	2.333±0.235^1
Dimer/monomer ratio	0.352±0.063	0.983±0.157^∗	0.035±0.024^1	0.154±0.097^1	0.004±0.003^1	0.016±0.016^1

^∗𝑃<0.05 versus cortex, ¹𝑃<0.05 versus control, and ²𝑃<0.05 versus high sucrose diet.