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International Journal of Endocrinology
Volume 2014, Article ID 203930, 7 pages
http://dx.doi.org/10.1155/2014/203930
Review Article

Meta-Analysis: Overweight, Obesity, and Parkinson's Disease

1Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050017, China
2Department of Physiology, College of Life Science, Hebei Normal University, Shijiazhuang 050024, China
3Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shijiazhuang 050000, China

Received 28 October 2013; Revised 7 December 2013; Accepted 9 December 2013; Published 5 February 2014

Academic Editor: Kristin Eckardt

Copyright © 2014 Jinhu Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Parkinson's disease (PD) is a severe neurological disease and its risk factors remain largely unknown. A meta-analysis was carried out to investigate the relationship of overweight and obesity with PD. Methods. We used PubMed, EMBASE, and the Chinese National Knowledge Infrastructure (CNKI) databases to identify studies of associations between overweight/obesity and PD. Overweight, obesity, and PD were used as keywords, and published works were retrieved until September 30, 2013. The extracted data were classified according to BMI values and analyzed using RevMan5.2 and Stata11.0. Results. Four cohort studies and three case-control studies were used to evaluate the association between overweight/obesity and PD, including 2857 PD patients and 5, 683, 939 cases of non-PD controls. There was a statistically significant difference between in the cohort study ( , 95% , 1.03–1.32,   ), but there was no difference between or , where the respective was 1.16 and 0.84; the respective 95% was 0.67–2.01 and 0.61–1.15, respectively, and the values were 0.60 and 0.28, respectively. Case-control studies showed that there was no statistical difference between any two groups. Conclusion. Meta-analysis showed that overweight might be a potential risk factor of PD. Demonstration of a causal role of overweight/obesity in PD development could have important therapeutic implications.