Review Article
Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis
Table 3
Effect of GH and IGF-1 administration on bone fractures healing.
| | Authors | Number of
subjects | Age | Type of fracture | Therapy | Dose GH
(mg/kg/day) | Duration | Results |
| | Van der Lely et al., 2000 [274] | Placebo = 46
W = 42
M = 13 |
| Hip fracture | rHGH | 0.02 | 6 weeks | 75% of patients return to the prefracture living situation |
| | Boonen et al., 2002 [270] | | 65–90 | Hip fracture | rhIGF-I/IGFBP-3 | 0.5 = 9
1.0 = 11 | 8 weeks
6 months | Increase bone density and muscle strength and enhance functional recovery |
| | Yeo et al., 2003 [275] | 31 W | 86 medium | Hip fracture | rHGH | 0.05 (high dose) or
0.025 (low dose) | 14 days | Significant increase of serum IGF-I and IGFBP-3 and promotes anabolism |
| | Weissberger et al., 2003 [276] | 33 W | 60–82 | Total hip replacement | rHGH | 0.012 | 14 weeks preoperatively and 4 weeks postoperatively | Improvements in lean body mass and skeletal muscle mass |
| | Hedström et al., 2004 [277] | 20 W | <65 | Hip fracture | rHGH | 0.1 U max 8 U | 4 weeks | IGF-I increased significantly and lean body mass and BMC preserved |
| | Raschke et al., 2007 [278] | 406
93 W +
313 M | 18–64 | Tibial fracture | rHGH | 15, 30, or 60 | 16 weeks | GH did not accelerate time to healing in open fracture |
| | Krusenstjerna-Hafstrøm et al., 2011 [279] | 406
(313 males and 93 females) | | Tibial fracture | rHGH | 15, 30, or 60 | 16 weeks | Dose-dependent increases of bone markers* |
|
|
M = men, W = women.
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