Abdominal Fat and Sarcopenia in Women Significantly Alter Osteoblasts Homeostasis In Vitro by a WNT/β-Catenin Dependent Mechanism

Figure 1

Expression of (a) Runx2, (b) BMP4, (c) ALP bone isoform d, (d) osteocalcin (OCN), and (e) osteopontin (OPN) in osteoblasts as measured by quantitative real-time PCR. Cells were grown in presence of sera from healthy normal body weight control individuals (CTL); obese patients (O); obese osteopenic patients (OO); obese sarcopenic patients (OS); obese sarcopenic osteopenic patients (OSO) as described in Section 2. Differences were considered significantly different when a 𝑃<0.05 was obtained ^∗𝑃<0.05 versus CTL; ^§𝑃<0.05 versus O.

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