Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid

Table 1

Clinicopathological features and the NRAS mutation status of 123 follicular neoplasms (FNs).

	Patients with a NRAS negative; FN	Patients with a NRAS positive; FN	-value
Average FN size (cm)	2.2 ± 1.5	1.4 ± 0.8	<0.001
Age
45 years	31 (65%)	17 (35%)	0.086
>45 years	59 (79%)	16 (21%)
Gender
Female	71 (74%)	25 (26%)	0.710
Male	19 (70%)	8 (30%)
Final results of FNs
Benign	52 (83%)	11 (17%)	0.016
Malignancy	38 (63%)	22 (37%)
Final results of coexisting nodules*
Benign	26 (83%)	10 (28%)	0.080
Malignancy	12 (63%)	12 (50%)
Total risk of malignancy	53% (47/90)	79% (26/33)	0.008

Of all 123 patients, 60 had one or more incidental nodules in addition to index nodule with a preoperative diagnosis of FN.