Mild Adrenal Steroidogenic Defects and ACTH-Dependent Aldosterone Secretion in High Blood Pressure: Preliminary Evidence

Table 2

Steroidogenesis in patients with no defect (A) or with the 21OHD (B) or 11OHD (C).

	No defect (A); (38)	21OHD (B); (13)	11OHD (C); (14)
17OHP baseline (ng/mL)	2 ± 1	2 ± 1	3 ± 13^c
17OHP 30 min (ng/mL)	5 ± 2	10 ± 1^a,c	15 ± 11^b,c
17OHP 60 min (ng/mL)	5 ± 2	11 ± 2^a,c	15 ± 11^b,c
C17OHP 60 min^1	8.7 ± 5.4	4.3 ± 1.6^a	3.2 ± 1.8^b
S baseline (ng/mL)	2 ± 1	2 ± 1	4 ± 2^b
S 30 min (ng/mL)	4 ± 1	6 ± 2^a,c	12 ± 6^b,c
S 60 min (ng/mL)	5 ± 2	6 ± 1^a,c	14 ± 3^b,c
CS 60 min^2	8.1 ± 3.0	7.0 ± 2.6^c	3.0 ± 0.5^b,c

C17OHP 60 min cortisol/17OHP ratio at 60 min, arbitrary units; ²CS 60 min cortisol/S ratio at 60 min, arbitrary units; ^asignificant differences between groups B and A; ^bsignificant differences between groups C and A; ^csignificant differences between groups C and B; in every case post hoc analysis when analysis of variance between the three groups revealed significant differences.