Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients

Table 5

OR (95% CI) for metastasis of PTC by ATM gene polymorphisms according to different models of inheritance (adjusted by age and stage). < 0.05 in bold.

SNP, genotype	Male		Female
	OR (95% CI)		OR (95% CI)
rs664677
CC^a	1.00		1.00
CT	0.36 (0.04–3.41)	0.54	4.32 (0.54–34.27)	0.95
TT	0.63 (0.14–2.73)	0.38	1.03 (0.40–2.66)	0.17
CT + TT versus CC^b	0.98 (0.35–2.75)	0.97	0.74 (0.39–1.41)	0.36
TT versus CC + CT^c	0.75 (0.21–2.64)	0.65	2.03 (0.86–4.82)	0.11
CT versus CC + TT^d	1.17 (0.44–3.12)	0.75	0.54 (0.29–1.00)	0.05
Risk per T allele^e	0.91 (0.46–1.80)	0.78	1.05 (0.66–1.67)	0.84
rs373759
GG^a	1.00		1.00
GA	1.94 (0.43–8.73)	0.39	3.11 (0.98–9.88)	0.06
AA	4.67 (0.34–65.00)	0.25	3.01 (0.34–26.90)	0.32
GA + AA versus GG^b	1.81 (0.62–5.31)	0.27	0.98 (0.52–1.84)	0.96
AA versus GG + GA^c	0.81 (0.15–4.24)	0.80	1.66 (0.68–4.07)	0.27
GA versus GG + AA^d	1.83 (0.67–4.99)	0.24	0.78 (0.42–1.44)	0.43
Risk per A allele^e	1.34 (0.60–2.98)	0.48	1.13 (0.71–1.78)	0.61
rs4988099
AA^a	1.00^f		1.00
AG	0.73 (0.13–3.97)	0.71	0.52 (0.17–1.57)	0.24
AG + GG versus AA^b	—	—	0.68 (0.24–1.94)	0.46
AG versus AA + GG^c	—	—	0.70 (0.25–2.00)	0.50
Risk per G allele^e	—	—	0.68 (0.24–1.88)	0.44
rs189037
GG^a	1.00		1.00
GA	1.58 (0.23–10.87)	0.64	0.15 (0.04–0.56)	0.01
AA	0.78 (0.05–13.51)	0.87	0.08 (0.01–0.74)	0.03
GA + AA versus GG^b	1.87 (0.52–6.74)	0.33	0.49 (0.25–0.98)	0.04
AA versus GG + GA^c	0.55 (0.14–2.09)	0.37	1.29 (0.58–2.86)	0.53
GA versus GG + AA^d	2.18 (0.78–6.11)	0.13	0.47 (0.25–0.89)	0.02
Risk per A allele^e	1.03 (0.47–2.25)	0.95	0.79 (0.49–1.25)	0.31

Codominant model (wild homozygote serves as the reference).
^bDominant model (combined heterozygote and homozygote for the minor allele versus wild homozygote).
^cRecessive model (minor allele homozygote versus combined heterozygote and homozygote for the wild allele).
^dOverdominant model (heterozygote versus combined homozygote for the wild and minor alleles).
^eMultiplicative model (uses allele frequencies).
^fJust gives OR (95% CI) and -value for heterozygote versus wild homozygote (no GG genotype for males).