Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients

Table 6

Associations between ATM haplotypes and risk of metastasis (adjusted by age and stage).

Haplotype	SNP^a			Frequency			OR (95% CI)
	1	2	3	Total	Metastasis (−)	Metastasis (+)
Male
1	C	G	G	0.4512	0.4699	0.4324	1.00	—
2	T	A	A	0.3387	0.3217	0.3600	1.14 (0.47–2.75)	0.78
3	T	G	A	0.0794	0.1010	0.0532	0.43 (0.09–2.13)	0.31
4	C	A	A	0.0658	0.0462	0.0852	2.42 (0.43–13.79)	0.32
5	C	G	A	0.0308	0.0405	0.0220	1.39 (0.14–13.42)	0.78
6	T	G	G	0.0223	0.0207	0.0240	2.97 (0.24–37.16)	0.40
Rare^b	—	—	—	0.0118	0.0000	0.0232	—	—
Female
1	C	G	G	0.5330	0.5228	0.5494	1.00	—
2	T	A	A	0.3142	0.2983	0.3386	1.00 (0.60–1.66)	0.99
3	T	G	A	0.0532	0.0687	0.0295	0.30 (0.08–1.10)	0.07
4	C	A	A	0.0460	0.0529	0.0361	0.54 (0.16–1.84)	0.32
5	T	G	G	0.0241	0.0240	0.0241	1.45 (0.38–5.51)	0.58
6	C	G	A	0.0224	0.0294	0.0106	0.35 (0.06–2.13)	0.26
Rare^b	—	—	—	0.0070	0.0039	0.0117	3.03 (0.18–52.22)	0.45

SNP are as follows: 1: rs664677; 2: rs373759; 3: rs189037.
^bRare: haplotypes with frequencies <0.01.