Gene Expression Profiling of the Paracrine Effects of Uterine Natural Killer Cells on Human Endometrial Epithelial Cells

Table 4

Transcripts that were altered by more than twofold in endometrial epithelial cells by stimulation with ZDY and uNK cell-secretion medium (𝑃<0.001). The transcript levels were obtained using a GeneChip PrimeView Human Gene Expression Array.

Gene symbol	Fold change	Gene ID	Description
Upregulated genes: 18 transcripts
Intracellular/signalling factors
AKR1C2	2.7	1646	Aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
Structural factors
TLN1	2.7	7094	Talin 1
KRT75	2.0	9119	Keratin 75
Transcription
NUPR1	2.6	26471	Nuclear protein, transcriptional regulator, 1
Ion binding
S100A8	2.1	6279	S100 calcium binding protein A8
Enzyme activity
ASNS	5.2	440	Asparagine synthetase (glutamine-hydrolyzing)
AKR1C1	3.3	1645	Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
NQO1	2.9	1728	NAD(P)H dehydrogenase, quinone 1
CBS	2.5	875	Cystathionine-beta-synthase
AKR1C3	2.3	8644	Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
PSAT1	2.2	29968	Phosphoserine aminotransferase 1
HMOX1	2.2	3162	Heme oxygenase (decycling) 1
GPX2	2.2	2877	Glutathione peroxidase 2 (gastrointestinal)
DHRS3	2.1	9249	Dehydrogenase/reductase (SDR family) member 3
H1FX	2.1	8971	H1 histone family, member X
Others
SLC7A11	3.1	23657	Solute carrier family 7 (anionic amino acid transporter light chain, xc-system), member 11
CTH	2.4	1491	Cystathionase (cystathionine gamma-lyase)
HSPB8	2.2	26353	Heat shock 22 kda protein 8
Downregulated genes: 33 transcripts
Cytokines/membrane proteins/signalling factors
CXCL3	−2.1	2921	Chemokine (C-X-C motif) ligand 3
CAPRIN2	−2.0	65981	Caprin family member 2
Transporters
COG5	−2.0	10466	Component of oligomeric golgi complex 5
Structural factors
LMNB1	−5.5	4001	Lamin B1
PNN	−2.9	5411	Pinin, desmosome associated protein
MFAP5	−2.2	8076	Microfibrillar associated protein 5
RPL37A	−2.2	6168	Ribosomal protein l37a
Transcription
HIRA	−3.6	7290	HIR histone cell cycle regulation defective homolog A (S. Cerevisiae)
YAP1	−2.4	10413	Yes-associated protein 1
ZNF226	−2.4	7769	Zinc finger protein 226
TAF15	−2.1	8148	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kda
NFKBIZ	−2.1	64332	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Ion binding
ZDHHC11	−2.2	79844	Zinc finger, DHHC-type containing 11
RNF145	−2.1	153830	Ring finger protein 145
Kinase
AHSA2	−2.0	130872	AHA1, activator of heat shock 90 kda protein atpase homolog 2 (yeast)
Enzyme activity
TNKS2	−7.7	80351	Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Nucleotide metabolism
RAD23B	−2.0	5887	RAD23 homolog B (S. Cerevisiae)
RCC1	−2.0	1104	Regulator of chromosome condensation 1
Others
GOLGA8A	−5.4	23015	Golgin A8 family, member A
LUC7L3	−3.8	51747	LUC7-like 3 (S. Cerevisiae)
HNRNPA2B1	−2.9	3181	Heterogeneous nuclear ribonucleoprotein A2/B1
XIST	−2.8	7503	X (inactive)-specific transcript (non-protein coding)
SNORA33	−2.6	594839	Small nucleolar RNA, H/ACA box 33
SNHG12	−2.5	85028	Small nucleolar RNA host gene 12 (non-protein coding)
C20orf197	−2.4	284756	Chromosome 20 open reading frame 197
EML2	−2.4	24139	Echinoderm microtubule associated protein like 2
PNISR	−2.3	25957	PNN-interacting serine/arginine-rich protein
KIAA0020	−2.3	9933	Kiaa0020
HMMR	−2.2	3161	Hyaluronan-mediated motility receptor (RHAMM)
NOP58	−2.2	51602	NOP58 ribonucleoprotein homolog (yeast)
PILRB	−2	29990	Paired immunoglobin-like type 2 receptor beta
NCAPG	−2	64151	Non-SMC condensin I complex, subunit G
PICALM	−2	8301	Phosphatidylinositol binding clathrin assembly protein