Sexual Well-Being in Adult Male Patients with Congenital Adrenal Hyperplasia
Table 2
Biochemical and hormonal parameters in 17 male patients with 21-OHD at study start (baseline) and after 2-year follow-up.
Baseline
Follow-up
BMI (kg/m2)
26.2 ± 5.5 (16.5–38)
25.5 ± 5.6 (19–38.5)
BP systolic/diastolic (mmHg)
118/78 ± 12/8 (100–135/60–90)
117/73* ± 17/10 (90–145/60–90)
Potassium (mmol/L)
3.76 ± 0.43 (3.2–4.7)
3.92 ± 0.34 (3.4–4.6)
Sodium (mmol/L)
140.8 ± 1.8 (136–144)
139.5 ± 2.7 (134–143)
Cholesterol (mg/dL)
169 ± 36 (126–237)
185 ± 43 (106–247)
Triglycerides (mg/dL)
103 ± 57 (44–219)
116 ± 62 (48–256)
ACTH (pg/mL)
153 ± 331 (5–1250)
62 ± 141 (5–561)
17-OHP (ng/mL)
14.9 ± 18.8 (0.8–50)
25.2 ± 58.8 (0.8–218)
Androstenedione (ng/mL)
1.55 ± 2.39 (0.2–10)
1.85 ± 3.15 (0.2–10.4)
DHEAS (ng/mL)
620 ± 778 (90–3395)
442 ± 378 (1–1246)
Testosterone (ng/mL)
5.0 ± 2.6 (1.7–9.6)
4.4 ± 2.6 (1.5–9.5)
SHBG (nmol/L)
41 ± 20 (14–77)
44 ± 25 (12–99)
Free testosterone index
46.3 ± 20.5 (15.4–100.6)
40.1 ± 24.4 (7.3–113.8)
AD/T ratio
0.41 ± 0.57 (0.06–1.96)
0.45 ± 0.81 (0.06–3.26)
Estradiol (pg/mL)
26.6 ± 8.0 (15.6–41.1)
21.8 ± 12.2 (5.0–49.5)
Renin (ng/L)
84.3 ± 130.7 (2.5–330)
288.7 ± 767.7 (2.5–2592)
LH basal (U/L)
4.1 ± 2.2 (1.5–8.9)
3.8 ± 2.9 (0.6–7.9)
LH peak (U/L)
31.9 ± 12.3 (13.5–61.3)
25.7 ± 16.8 (0.8–53.4)
max LH
27.8 ± 11.1 (7.9–53.6)
22.0 ± 15.5 (0.3–46.2)
FSH basal (U/L)
7.1 ± 6.8 (2.3–28.9)
6.1 ± 4.0 (1.9–12.9)
FSH peak (U/L)
12.9 ± 11.1 (4.4–46)
9.5 ± 8.5 (1.0–26.2)
max FSH
5.9 ± 4.8 (0.6–17.1)
4.3 ± 4.5 (1.0–13.3)
Daily GC equivalent dose/m2 BSA (mg/m2)
19.8 ± 5.8 (10.0–33.3)
18.6 ± 6.9 (9.2–30.6)
Data are means ± SD (range). BMI: body mass index; BP: blood pressure; BSA: body surface area. Normal ranges (SI units shown in brackets): sodium 134–145 mmol/L; potassium 3.4–5.2 mmol/L; cholesterol < 200 mg/dL (5.17 mmol/L); triglycerides < 180 mg/dL (2.06 mmol/L). Conversion factors: androstenedione (AD) X3.49 nmol/liter; testosterone (T) X3.47 nmol/liter; 17-hydroxy-progesterone (17OHP) X3.026 nmol/liter; estradiol X3.67 pmol/liter; and DHEAS X2.57 nmol/liter. max denotes the differences between peak and basal LH or FSH concentration. The dose of daily glucocorticoid was converted into milligrams of daily hydrocortisone equivalent (1 mg dexamethasone = 14 mg prednisolone = 70 mg hydrocortisone). Free testosterone index (fTI) was calculated by the ratio 347 * testosterone (ng/mL)/SHBG (nmol/L) [31]. Renin was measured only in SW CAH patients. versus baseline.
