Long-Term Follow-Up of Patients with 46,XY Partial Gonadal Dysgenesis Reared as Males

Table 3

Data on growth, puberty, semen analysis, and surgical procedures undergone by ten patients with partial gonadal dysgenesis.

Patient	1	2	3	4	5	6	7	8	9	10
Target height (cm)	168.3	171.5	165.5	170	182.2	169.7	—	170.5	182.5	176.7
Target height ( score)	−1.17	−0.73	−1.57	−0.94	+0.77	−0.99	—	−0.87	+0.80	−0.0
Final height (cm)	170.2	175	165	*	175	165.5	180	171	171	174
Final height ( score)	−0.89	−0.19	−1.51	—	−0.11	−1.58	+0.57	−0.76	−0.76	+0.30
Age of pubarche	12.5	9.5	13	12.5	11.5	15	11.5	10.5	11	13.5
Tanner staging at last visit (years)	G4P5 (18.4)	G5P5 (18.3)	G4P4 (17.7)	G4P4 (15.5)	G5P5 (17.4)	G5P5 (19.8)	G4P4 (17.5)	G4P4 (18.6)	G5P5 (18.5)	G3P3^# (17.6)/G4P4 (17.9)
Testicular volume (mL) at last visit (right/left)	NA	4/8	2/5	6/8	12/12	20/—	20/—	10/20	NA	—/8
Sperm analysis (optical microscopy)	NP	NP	NP	NP	Low viscosity, rare spz (some motile)	High viscosity, rare spz (all immotile)	Normal viscosity, rare spz (some motile)	NP	NP	NP
Surgical procedures	Orthophalloplasty (11 mo); hypospadias correction (4 surgeries between 1 and 2 y)	Orchidopexy + hypospadias correction (2 y 8 mo)	Orchidopexy (3 y 3 mo); hypospadias correction (7 y); fistula correction (12, 13, 14, and 18 y)	Hypospadias correction (1 y 7 mo); fistula correction (2 y 8 mo and 2 y 9 mo)	Hypospadias correction (1 y 4 mo); fistula correction (4 y and 5 y)	Hypospadias correction (8 y 8 mo); fistula correction (9 and 12 y)	Orchidopexy (5 y)	Orchidopexy + orthophalloplasty (2 y 5 mo); fistula correction (3, 4, and 14 y)	Orchidopexy + hypospadias correction (2 y 2 m); fistula correction (5 and 9 y)	Inguinal hernia correction + orchidopexy (3 m); hypospadias correction (4 y)

Did not attain final height; ^#before testosterone replacement and associated with gynecomastia; after testosterone replacement; NA: not available; NP: not performed; spz: spermatozoa.