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International Journal of Endocrinology
Volume 2014, Article ID 483718, 9 pages
Research Article

Behavioural Outcome in Children with Congenital Adrenal Hyperplasia: Experience of a Single Centre

1Department of Paediatrics, Hospital Putrajaya, Pusat Pentadbiran Putrajaya, Presinct 7, 62250 Putrajaya, Malaysia
2Department of Paediatrics, Universiti Kebangsaan Malaysia Medical Centre (UKMMC) Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia

Received 19 October 2013; Revised 13 February 2014; Accepted 3 March 2014; Published 1 April 2014

Academic Editor: Maria L. Dufau

Copyright © 2014 Arini Nuran Idris et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to determine the behavioral outcome in children with CAH and to identify the risk factors that may influence it. Participants (aged 6–18 years) included 29 girls and 20 boys with CAH and unaffected siblings (25 girls and 17 boys). Psychological adjustment was assessed with parent reports on the Child Behavior Checklist (CBCL). Information about disease characteristics was obtained from medical records. Our study reveals that there was higher incidence of parent-reported problem of anxious/depressed and withdrawn/depressed behaviours, somatic complaints, social, thought, and attention problems, and rule-breaking, aggressive, internalizing, and externalizing behaviour among children with CAH compared to controls. The prevalence of internalizing behaviour problems was higher in CAH boys compared with that of controls. Psychosocial adjustment of girls with CAH was found to be similar to unaffected female controls and was within the normal population range. Family income may be associated with behavioral outcome. Glucocorticoid dose may reflect disease severity which may be associated with behavioral outcome. We conclude that internalizing behavioral problem was prevalent among boys with CAH reflecting maladaptive adjustment in coping with chronic illness. This highlighted the importance of psychological and social support for the patients and their families.