Appetite Response among Those Susceptible or Resistant to Obesity
Table 2
Hormone profiles in obesity resistant individuals (ORI) and obesity susceptible individuals (OSI) in response to a standardised meal.
ORI
OSI
P value*
P value†
P value‡
Females
Males
Females
Males
n
Median
Interquartile Range
n
Median
Interquartile Range
n
Median
Interquartile Range
n
Median
Interquartile Range
Ghrelin
Fasting (pg·mL−1)
14
70.7
39.2–129.5
17
55.2
38.6–137.3
12
69.3
59.5–105.5
12
55.0
35.6–65.1
0.319
0.600
0.662
AUC (mmol·min−1)
11
12596
7470–16987
16
11341
8747–21848
9
11232
9252–14968
9
9889
6136–10693
0.857
0.460
0.751
Nadir (pg·mL−1)
16
44.9
31.5–55.3
17
33.7
27.1–56.7
14
39.4
31.2–46.7
13
35.3
18.0–38.7
0.419
0.287
0.822
Time to nadir (min)
16
60
30–60
17
60
60-60
14
30
30–60
13
60
60-60
0.058
0.518
0.580
PYY
Fasting (pg·mL−1)
14
47.9
40.1–53.7
17
55
47.8–65.3
14
47.1
37.5–67.3
12
56.4
49.4–62.0
0.161
0.889
0.761
AUC (mmol·min−1)
13
11700
10954–13230
16
12511
10524–13597
12
12779
10777–18752
9
12877
12436–13739
0.825
0.601
0.736
Peak (pg·mL−1)
16
72.6
68.2–82.0
17
77.8
66.7–87.5
15
75.4
55.0–112.4
13
75.7
68.7–87.5
0.981
0.877
0.916
Time to peak (min)
16
60
45–120
17
60
30–120
15
120
60–180
13
30
30-30
0.275
0.584
0.526
Leptin
Fasting (pg·mL−1)
16
2426
1367–3626
17
693.4
440.9–1495.0
15
14367
4135–24941
12
2480
1424–8725
<0.001
<0.001
0.324
AUC (mmol·min−1)
16
425506
231672–582562
16
101878
74897–237294
14
1753714
502753–4671533
9
410572
268776–1746261
<0.001
<0.001
0.378
Nadir (pg·mL−1)
16
2003
1184–2986
17
531.7
339.7–1313.4
15
9015
2661–24450
13
2108
1198–6836
0.003
0.001
0.946
Time to nadir (min)
16
60
15–120
17
60
30–120
15
60
15–120
13
60
30–120
0.781
0.558
0.949
Glucose
Fasting (mmol·L−1)
16
5.30
5.00–5.53
17
5.25
4.95–5.40
15
5.25
5.05–5.30
13
5.25
5.05–5.50
0.851
0.900
0.887
AUC (mmol·min−1)
16
1030
995–1063
17
1054
1013–1081
15
1062
970–1128
13
1048.0
992–1113
0.298
0.252
0.954
Peak (mmol·L−1)
16
6.9
6.70–7.55
17
7.3
7.00–8.00
15
7.2
6.7–7.8
13
7.5
7.10–7.60
0.038
0.540
0.759
Time to peak (min)
16
15
15–30
17
30
30-30
15
30
15–30
13
30
30-30
0.103
0.072
0.352
Insulin
Fasting (pg·mL−1)
13
157
131.1–177.1
15
236.7
110.3–299.6
14
252.2
187.0–355.5
11
398
281.3–466.5
0.085
0.004
0.213
AUC (mmol·min−1)
12
105038
92640–143522
14
139943
108035–171234
12
175434
104685–217197
8
213250
131498–321104
0.057
0.016
0.802
Peak (pg·mL−1)
16
1345.1
965.9–1867.8
17
1677.5
1250.4–2298.3
15
1467.9
1098.9–2294.6
13
1849
1453–2475
0.145
0.196
0.632
Time to peak (min)
16
30
30-30
17
30
30-30
15
30
30-30
13
30
30-30
0.466
0.379
0.716
%BF: percent body fat, AUC: area under the curve, ORS: obesity resistance/susceptibility category. Fasting and AUC data have been log transformed, *P value for sex adjusted for ORS, †P value for ORS adjusted for sex, ‡P value for ORS adjusted for sex and %BF.
