Etiopathogenesis of Sheehan’s Syndrome: Roles of Coagulation Factors and TNF-Alpha
Table 2
Distribution of thrombophilic and cytokine genes among Sheehan’s Syndrome cases and controls.
Sheehan’s Syndrome patients (n: 53)
Controls (n: 43)
OR (95% CI)
P value‡
n
(%)
n
(%)
MTHFR C677T
Genotype
CC (normal)
31
58.5
25
58.1
1 (Ref)
—
CT (heterozy.)
19
35.8
13
30.2
1.179 (0.489–2.843)
0.714
TT (homozy.)
3
5.7
5
11.6
0.484 (0.105–2.224)
0.351
P value†
0.538
MTHFR A1298C
Genotype
AA (normal)
17
32.1
15
34.9
1 (Ref)
—
AC (heterozy.)
28
52.8
19
44.2
1.3 (0.525–3.219)
0.570
CC (homozy.)
8
15.1
9
20.9
0.784 (0.241–2.549)
0.686
P value†
0.646
Factor II G20210A
Genotype
GG (normal)
50
94.3
42
97.7
1 (Ref)
—
GA (heterozy.)
3
5.7
1
2.3
2.520 (0.253–25.136)
0.431
AA (homozy.)
—
—
—
—
—
—
P value†
0.416
Factor V G1691A
Genotype
GG (normal)
47
88.7
37
86
1 (Ref)
—
GA (heterozy.)
5
9.4
4
9.3
0.984 (0.247–3.925)
0.982
AA (homozy.)
1
1.9
2
4.7
0.394 (0.034–4.511)
0.454
P value†
0.741
PAI-1 4G/5G
Genotype
5G/5G (normal)
21
39.6
7
16.3
1 (Ref)
—
4G/5G (heterozy.)
20
37.7
26
60.5
0.256 (0.091–0.722)
0.01
4G/4G (homozy.)
12
22.6
10
23.3
0.4 (0.121–1.326)
0.134
P value†
0.03
TNF-α −308 G>A
Genotype
GG (normal)
43
81.1
34
79.1
1 (Ref)
—
GA (heterozy.)
9
17
9
20.9
0.791 (0.283–2.210)
0.654
AA (homozy.)
1
1.9
—
—
—
—
P value†
0.6
Notes: heterozy.: heterozygous; homozy.: homozygous. †Significance of χ 2 values which were obtained from a Chi-Square test. ‡Significance of odds ratios which were obtained from a logistic regression model.
