MicroRNAs in Diabetic Kidney Disease

Table 1

Summary of microRNAs in diabetic kidney disease (upregulation).

microRNA	In vitro (cell type)	In vivo (animal mode)	Target	References
miR-192	MCs (human, rat, and mouse)	STZ induced DN mice,; DN in db/db mice	Sip-1	[48–50, 52–54]
miR-216a miR-217	Primary MCs (mouse)	STZ induced DN mice,; DN in db/db mice	PTEN	[56]
miR-216a	Primary MCs (mouse)	STZ induced DN mice,; DN in db/db mice	Ybx1	[57]
miR-200b/c	MCs (mouse)	STZ induced DN mice,; DN in db/db mice	Zeb1/2	[52, 90]
miR-215	Primary MCs (mouse)	db/db mice	CTNNBIP1	[50]
miR-21	MCs (human and rat) PTEs (mouse)	OVE26 type 1 diabetic; mice (12 weeks of age)	PTEN	[64]
	MCs, TECs (rat)	db/db mice (10 or 20 weeks of age)	Smad7	[63]
		kk-ay DN mice (T2DM); (20 weeks of age)	MMP-9	[65]
miR-29c	MCs (mouse)	db/db mice	Sprouty homolog-1	[49]
miR-377	MCs (human and mouse)	spontaneous [(NOD/Lt) mice] and STZ induced DN mice	PAK1 and MnSOD	[53]
miR-192; miR-29c; miR-26b; miR-200b	Mouse podocytes; Mouse kidney; Microvascular; Endothelial cells			[53]

PTE: proximal tubule epithelial cells; TEC: tubular epithelial cells; MC: mesangial cells; STZ: streptozotocin; DN: diabetic nephropathy.