Review Article
MicroRNAs in Diabetic Kidney Disease
Table 2
Summary of microRNAs in diabetic kidney disease (downregulation).
| microRNA | In vitro (cell type) | In vivo (animal mode) | Target | References |
| miR-192 | PTE human (HK-2 cells) | Patients with established DN | Zeb2 | [60, 61] | miR-215 | Primary MCs and PTCs (rat) | STZ induced DN in APOE knockout mice (10 weeks of age) | Zeb2 | [61] | miR-21 | Primary MCs (mouse) | db/db mice (8 weeks of age) | PTEN | [67] | miR-200a | TEC (rat) | STZ induced DN in apolipoprotein E knockout mice | TGF-β2 | [88] | miR-29a | PTE human (HK-2 cells) | | Col IVA1 and Col IVA2 | [77] | miR-25 | MCs (rat) | STZ induced DN rat | Nox4 | [95] | miR-451 | Primary MCs (mouse) | Early DN (db/db mice) | Ywhaz | [96] | miR-93 | Renal microvascular Endothelial cell Mouse podocytes | db/db mice | VEGF-A | [94] |
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PTE: proximal tubule epithelial cells; TEC: tubular epithelial cells; MC: mesangial cells; STZ: streptozotocin; DN: diabetic nephropathy.
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