Influence of the A3669G Glucocorticoid Receptor Gene Polymorphism on the Metabolic Profile of Pediatric Patients with Congenital Adrenal Hyperplasia

Table 1

Clinical and anthropometric characteristics of 41 pediatric CAH patients.

Variables	Salt wasters (𝑛=26)	Simple virilizing (𝑛=15)	𝑃 value
Age, mean (SD), years	10.6 (4.1)	12.8 (3.4)	0.090
Obesity, 𝑛 (%)	10 (38.4)	3 (20)	0.381
Metabolic Syndrome, 𝑛 (%)	4 (15.4)	2 (13.3)	0.780
GC dose, mean (SD), mg/m^2	9.6 (2.9)	11.1 (4.9)	0.428
Duration of GC therapy, mean (SD), years	10.7 (4.5)	9.3 (4.0)	0.423
𝑧BMI, mean (SD), kg/m^2	1.04 (1.09)	0.90 (0.74)	0.658
Waist circumference, mean (SD), cm	66.4 (11.0)	70.8 (7.3)	0.177
Hip, mean (SD), cm	80.3 (12.9)	88 (9.1)	0.052
Hip-waist ratio, mean (SD)	0.83 (0.06)	0.80 (0.04)	0.207
Increased waist circumference, (SD), 𝑛 (%)	13 (50)	8 (53.3)	0.906
Fasting glucose, mean (SD), mg/dL	82.4 (8.1)	85.1 (10.7)	0.368
Fasting insulin mean (SD), 𝜇lU/mL	12.7 (9.5)	13.9 (10.8)	0.548
HOMA-IR, mean (SD)	1.58 (1.15)	1.73 (1.30)	0.547
HOMA-S, mean (SD)	94.7 (58.7)	82.1 (50.1)	0.494
HOMA-B, mean (SD)	155.0 (75.8)	157.9 (78.8)	0.845
Total cholesterol, mean (SD), mg/dL	159.2 (33.7)	136.6 (23.7)	0.033
HDL-c, mean (SD), mg/dL	44.2 (12.8)	51.0 (56.6)	0.163
LDL-c, mean (SD), mg/dL	99.8 (30.7)	75.2 (12.3)	0.006
Triglycerides, mean (SD), mg/dL	76.4 (33.0)	52.4 (17.0)	0.014
Increased blood pressure, 𝑛 (%)	2 (7.7)	2 (13.3)	0.968