Influence of the A3669G Glucocorticoid Receptor Gene Polymorphism on the Metabolic Profile of Pediatric Patients with Congenital Adrenal Hyperplasia

Table 2

Influence of A3669G polymorphism on the metabolic profile of CAH patients.

Variables	Genotypes		𝑃 value^a	Adjusted; 𝑃 value
	A3669G; 𝑛=7	Wild type; 𝑛=34
Obesity, 𝑛 (%)	3 (42.8)	10 (29.4)	0.802	0.568
Metabolic syndrome, 𝑛 (%)	1 (14.3)	5 (14.7)	0.576	0.819
GC dose, mean (SD), mg/m²	7.7 (3.5)	10.5 (3.9)	0.085	0.125
Duration of GC therapy, years	11.1 (4.2)	9.7 (5.0)	0.542	0.657
𝑧BMI, mean (SD)	1.63 (0.66)	0.77 (1.0)	0.037	0.226
Waist circumference, mean (SD), cm	72.0 (6.6)	67.8 (10.6)	0.331	0.089
Hip, mean (SD), cm	85.9 (10.8)	82.7 (12.4)	0.540	0.133
Hip-waist ratio, mean (SD)	0.84 (0.08)	0.81 (0.05)	0.176	0.279
Increased waist circumference, (SD), 𝑛 (%)	6 (85.7)	15 (34.1)	0.112	0.208
Fasting glucose, mean (SD), mg/dL	79.7 (3.4)	84.2 (9.8)	0.193	0.327
Fasting insulin mean (SD), 𝜇lU/mL	12.2 (5.9)	13.4 (10.6)	0.656	0.804
HOMA-IR, mean (SD)	1.51 (0.71)	1.67 (1.28)	0.695	0.787
HOMA-S, mean (SD)	76.1 (27.2)	92.9 (59.5)	0.469	0.578
HOMA-B, mean (SD)	162.8 (49.6)	154.7 (80.9)	0.444	0.797
Total cholesterol, mean (SD), mg/dL	162.6 (45.2)	147.2 (29.8)	0.281	0.237
HDL-c, mean (SD), mg/dL	39.1 (7.5)	48.3 (15.2)	0.132	0.176
LDL-c, mean (SD), mg/dL	110.9 (38.3)	85.3 (23.2)	0.029	0.021
Triglycerides, mean (SD), mg/dL	62.9 (23.3)	69.7 (34.2)	0.726	0.633
Increased blood pressure, 𝑛 (%)	1 (14.3)	3 (8.8)	0.798	0.752

Values are given as means ± SD.
Adjusted for age, sex, and clinical form.
aUnivariated analysis.