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International Journal of Endocrinology
Volume 2014, Article ID 607924, 9 pages
Research Article

Markers of Systemic Inflammation and Apo-AI Containing HDL Subpopulations in Women with and without Diabetes

1Department of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98124 Messina, Italy
2Department of Economical, Business and Environmental Sciences and Quantitative Methods, University of Messina, Piazza Pugliatti 1, 98122 Messina, Italy
3Lipid Metabolism Laboratory, JM-USDA-Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA

Received 4 July 2014; Accepted 19 August 2014; Published 2 September 2014

Academic Editor: Maria Chiara Rossi

Copyright © 2014 Giuseppina T. Russo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Besides their role in reverse cholesterol transport, HDL particles may affect the atherosclerotic process through the modulation of subclinical inflammation. HDL particles differ in size, composition, and, probably, anti-inflammatory properties. This hypothesis has never been explored in diabetic women, frequently having dysfunctional HDL. The potential relationship between lipid profile, Apo-AI containing HDL subclasses distribution, and common inflammatory markers (hsCRP, IL-6) was examined in 160 coronary heart disease- (CHD-) free women with and without type 2 diabetes. Results. Compared to controls, diabetic women showed lower levels of the atheroprotective large α-1, α-2, and pre-α-1 and higher concentration of the small, lipid-poor α-3 HDL particles ( all); diabetic women also had higher hsCRP and IL-6 serum levels (age- and BMI-adjusted ). Overall, HDL subclasses significantly correlated with inflammatory markers: hsCRP inversely correlated with α-1 and pre-α-1 ; IL-6 inversely correlated with α-1 , α-2 , and pre-α-1 and positively with α-3 HDL . Similar correlations were confirmed at univariate regression analysis. Conclusions. More atheroprotective HDL subclasses are associated with lower levels of inflammatory markers, especially in diabetic women. These data suggest that different HDL subclasses may influence CHD risk also through the modulation of inflammation.