Angiogenesis in Pituitary Adenomas: Human Studies and New Mutant Mouse Models

<div>Total (<i>Drd2 </i><sup>−/−</sup>) or lactotrope (LacDrd2KO) disruption of D2R evokes and increases in pituitary VEGF and CD31, with no alteration of PTTG or FGF2 content. Pituitary angiogenesis correlates with pituitary hyperplasia and increased prolactin synthesis and release.</div>

International Journal of Endocrinology

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Figure 2: Angiogenesis in Pituitary Adenomas: Human Studies and New Mutant Mouse Models 