Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2014, Article ID 628010, 5 pages
http://dx.doi.org/10.1155/2014/628010
Research Article

Evaluation of Postural Parathyroid Hormone Change in Patients with Primary Hyperparathyroidism

Endocrinology and Metabolism Department, Ataturk Education and Research Hospital, Yildirim Beyazit University, 06800 Ankara, Turkey

Received 29 May 2014; Revised 13 August 2014; Accepted 17 August 2014; Published 1 September 2014

Academic Editor: Iacopo Chiodini

Copyright © 2014 Cevdet Aydin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. In the present study, we aimed to investigate postural change of PTH in normal individuals and in patients with primary hyperparathyroidism (PHPT). Methods. Twenty-two patients with PHPT and nine healthy controls were enrolled. Following 12 h of fast, patients stayed in recumbent position for an hour and PTH and total Ca measurements were performed at the 45th and 60th minutes of resting. Afterwards, the patients resumed an upright posture for an hour and again blood samples were taken at the 45th and 60th minutes of standing. Results. In the PHPT group, mean PTH was calculated as 153.9 pg/mL in the recumbent position while it was 206.3 during upright position (Δ change was 47.7) (). In the control group mean serum PTH was measured as 41.2 pg/mL in the recumbent position while it was 44.8 pg/mL in the upright position (Δ change was 1.7) (). In both groups, serum Ca was higher in the upright position compared to the recumbent position (). Conclusion. Postural change of serum PTH is significant only in PHPT group. Postural PTH test may give a clue to the clinician when the diagnosis of PHPT is equivocal.