Central Hypogonadotropic Hypogonadism: Genetic Complexity of a Complex Disease

Figure 1

Scheme of all human CHH-related genes involved and supposed to be involved at different steps in the hypothalamic-pituitary-gonadal axis development and functioning. All three main steps leading to the HPG axis formation are reported in this picture. Upper side: list of the genes, implicated in the development of GnRH neurons and their migration towards the olfactory bulb, during the embryonic development. Middle part: genes involved in the regulation of GnRH secretion. Lower side: genes implicated in the direct action of GnRH on pituitary and in its indirect action on gonads.