Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents
Table 1
Anthropometric and biochemical data with different GAS6 rs8191973 genotypes among boys and girls.
Boys
Girls
GG
GC
CC
GG
GC
CC
(n = 277)
(n = 72)
(n = 9)
(n = 277)
(n = 85)
(n = 7)
BMI (kg/m2)
22.4 ± 4.0
21.7 ± 4.0
24.2 ± 2.8
21.1 ± 3.2
21.6 ± 3.7
21.1 ± 2.0
WC (cm)
80.1 ± 10.5
79.2 ± 10.4
84.7 ± 8.6
75.2 ± 7.8
76.5 ± 9.2
78.6 ± 6.8
hsCRP (mg/L)
0.8 ± 1.3
1.0 ± 1.3
1.0 ± 1.7
0.6 ± 0.9
0.6 ± 0.7
0.3 ± 0.2
TNF-α (pg/mL)
26.8 ± 2.9
23.5 ± 4.1
25.3 ± 6.2
22.7 ± 4.7
27.3 ± 5.4
25.1 ± 7.5
IL-6 (pg/mL)
3.2 ± 2.1
3.5 ± 3.1
3.9 ± 3.0
3.3 ± 3.1
3.0 ± 1.4
2.8 ± 1.1
Glucose (mg/dL)
94.1 ± 6.4
92.7 ± 5.8
93.7 ± 4.1
91.7 ± 6.4
91.1 ± 7.3
88.3 ± 3.5
Insulin (μU/mL)
15.4 ± 8.8
13.8 ± 8.3
17.1 ± 6.3
14.1 ± 7.5
15.7 ± 8.0
15.9 ± 5.1
HOMA-IR
3.6 ± 2.2
3.2 ± 2.1
4.0 ± 1.6
3.2 ± 1.8
3.6 ± 1.9
3.4 ± 1.0
Gas6 (ng/mL)
12.1 ± 3.3
14.1 ± 3.7
12.9 ± 3.7
12.6 ± 3.9
12.2 ± 3.1
11.8 ± 3.1
Data are expressed as mean ± SD. BMI: body mass index; WC: waist circumference; HOMA-IR: homeostasis model assessment of insulin resistance; hsCRP: high-sensitivity C-reactive protein; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6.
