Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents

Table 5

Logistic regression analyses of different GAS6 SNP on abnormal variables among adolescents.

Variables^b	GAS6 rs8191973		GAS6 rs8191974
	GG OR (95% CI)^a		GG OR (95% CI)^a
	Unadjusted	Adjusted^c	Unadjusted	Adjusted^c
Boys
High BMI	1.12 (0.47–2.68)	1.26 (0.34–4.76)	1.40 (1.06–2.99)^d	1.85 (1.04–3.23)^d
High WC	0.82 (0.38–1.76)	1.11 (0.39–5.26)	1.58 (1.18–2.01)^d	1.68 (1.08–3.25)^d
High hsCRP	1.87 (1.25–2.87)^d	2.53 (1.03–6.24)^d	1.88 (0.68–3.25)	1.92 (0.93–3.96)
High TNF-α	4.26 (0.99–18.37)	3.34 (0.42–24.98)	0.93 (0.43–1.98)	0.99 (0.33–2.94)
High IL-6	2.09 (0.92–4.82)	2.27 (0.98–5.26)	2.68 (1.32–5.20)^d	2.56 (1.33–5.00)^d
High HOMA-IR	1.41 (0.56–3.52)	1.14 (0.31–4.17)	1.28 (0.61–2.67)	2.35 (0.73–7.69)
Girls
High BMI	0.76 (0.36–1.61)	0.57 (0.22–1.45)	1.09 (0.53–2.26)	1.10 (0.43–2.86)
High WC	0.60 (0.30–1.23)	0.44 (0.17–1.11)	1.26 (0.60–2.64)	1.57 (0.55–4.55)
High hsCRP	0.90 (0.41–1.96)	1.04 (0.39–2.78)	1.19 (0.58–2.44)	1.05 (0.44–2.50)
High TNF-α	0.91 (0.41–2.04)	0.69 (0.24–1.96)	1.00 (0.47–2.13)	0.85 (0.31–2.33)
High IL-6	1.37 (0.61–3.09)	0.90 (0.34–2.50)	1.42 (0.69–2.95)	1.68 (0.06–4.55)
High HOMA-IR	0.76 (0.33–1.72)	0.69 (0.25–1.92)	1.48 (0.64–3.41)	2.20 (0.70–7.14)

aUnder a recessive model (using heterozygotes and minor homozygotes as the reference for each SNP). ^bAbnormal variables were determined using an age- and gender-specific 90th percentile cut-off point.
^cAdjusting for age, Tanner stage, cigarette smoking, alcohol drinking, and physical activity.
^dP < 0.05.
OR: odds ratio; CI: confidence index; BMI: body mass index; WC: waist circumference; HOMA-IR: homeostasis model assessment of insulin resistance; hsCRP: high-sensitivity C-reactive protein; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6.