Table 5: Logistic regression analyses of different GAS6 SNP on abnormal variables among adolescents.

VariablesbGAS6 rs8191973GAS6 rs8191974
GG OR (95% CI)aGG OR (95% CI)a
UnadjustedAdjustedcUnadjustedAdjustedc

Boys
 High BMI 1.12 (0.47–2.68)1.26 (0.34–4.76)1.40 (1.06–2.99)d1.85 (1.04–3.23)d
 High WC0.82 (0.38–1.76)1.11 (0.39–5.26)1.58 (1.18–2.01)d1.68 (1.08–3.25)d
 High hsCRP1.87 (1.25–2.87)d2.53 (1.03–6.24)d1.88 (0.68–3.25)1.92 (0.93–3.96)
 High TNF-α4.26 (0.99–18.37)3.34 (0.42–24.98)0.93 (0.43–1.98)0.99 (0.33–2.94)
 High IL-62.09 (0.92–4.82)2.27 (0.98–5.26)2.68 (1.32–5.20)d2.56 (1.33–5.00)d
 High HOMA-IR1.41 (0.56–3.52)1.14 (0.31–4.17)1.28 (0.61–2.67)2.35 (0.73–7.69)
Girls
 High BMI 0.76 (0.36–1.61)0.57 (0.22–1.45)1.09 (0.53–2.26)1.10 (0.43–2.86)
 High WC0.60 (0.30–1.23)0.44 (0.17–1.11)1.26 (0.60–2.64)1.57 (0.55–4.55)
 High hsCRP0.90 (0.41–1.96)1.04 (0.39–2.78)1.19 (0.58–2.44)1.05 (0.44–2.50)
 High TNF-α0.91 (0.41–2.04)0.69 (0.24–1.96)1.00 (0.47–2.13)0.85 (0.31–2.33)
 High IL-61.37 (0.61–3.09)0.90 (0.34–2.50)1.42 (0.69–2.95)1.68 (0.06–4.55)
 High HOMA-IR0.76 (0.33–1.72)0.69 (0.25–1.92)1.48 (0.64–3.41)2.20 (0.70–7.14)

Under a recessive model (using heterozygotes and minor homozygotes as the reference for each SNP). bAbnormal variables were determined using an age- and gender-specific 90th percentile cut-off point.
cAdjusting for age, Tanner stage, cigarette smoking, alcohol drinking, and physical activity.
dP < 0.05.
OR: odds ratio; CI: confidence index; BMI: body mass index; WC: waist circumference; HOMA-IR: homeostasis model assessment of insulin resistance; hsCRP: high-sensitivity C-reactive protein; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6.