Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2014, Article ID 683515, 15 pages
http://dx.doi.org/10.1155/2014/683515
Clinical Study

Effects of Long-Term Testosterone Therapy on Patients with “Diabesity”: Results of Observational Studies of Pooled Analyses in Obese Hypogonadal Men with Type 2 Diabetes

1Private Urology Practice, 27570 Bremerhaven, Germany
2Institute for Urology and Andrology, 22846 Norderstedt, Germany
3International University, 01067 Dresden, Germany
4Research Department, Gulf Medical University, Ajman, UAE
5Department of Epidemiology and Statistics, Boston University School of Public Health, Boston, MA 02118, USA
6Global Medical Affairs Andrology, Bayer Pharma, 13353 Berlin, Germany

Received 30 October 2013; Revised 23 December 2013; Accepted 24 December 2013; Published 11 March 2014

Academic Editor: Antonio Aversa

Copyright © 2014 Ahmad Haider et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [62 citations]

The following is the list of published articles that have cited the current article.

  • Michal Rabijewski, Lucyna Papierska, and Pawel Piatkiewicz, “The prevalence of prediabetes in population of Polish men with late-onset hypogonadism,” Aging Male, vol. 17, no. 3, pp. 141–146, 2014. View at Publisher · View at Google Scholar
  • Giovanni Corona, Elisa Maseroli, and Mario Maggi, “Injectable testosterone undecanoate for the treatment of hypogonadism,” Expert Opinion on Pharmacotherapy, pp. 1–24, 2014. View at Publisher · View at Google Scholar
  • Abdulmaged M. Traish, “Outcomes of Testosterone Therapy in Men with Testosterone Deficiency (TD) Part II,” Steroids, 2014. View at Publisher · View at Google Scholar
  • Mouna Zerradi, Julie Dereumetz, Marie-Michèle Boulet, and André Tchernof, “Androgens, body fat Distribution and Adipogenesis.,” Current obesity reports, vol. 3, no. 4, pp. 396–403, 2014. View at Publisher · View at Google Scholar
  • Mathis Grossmann, Rudolf Hoermann, Gary Wittert, and Bu B. Yeap, “Effects of testosterone treatment on glucose metabolism and symptoms in men with type 2 diabetes and the metabolic syndrome: a systematic review and meta-analysis of randomized controlled clinical trials,” Clinical Endocrinology, vol. 83, no. 3, pp. 344–351, 2014. View at Publisher · View at Google Scholar
  • Abdulmaged M. Traish, Andre T. Guay, and Michael Zitzmann, “5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: A medical hypothesis,” Hormone Molecular Biology and Clinical Investigation, vol. 20, no. 3, pp. 73–80, 2014. View at Publisher · View at Google Scholar
  • Abraham Morgentaler, Martin M. Miner, Monica Caliber, Andre T. Guay, Mohit Khera, and Abdulmaged M. Traish, “Testosterone Therapy and Cardiovascular Risk: Advances and Controversies,” Mayo Clinic Proceedings, 2014. View at Publisher · View at Google Scholar
  • Abdulmaged M. Traish, “Testosterone and weight loss,” Current Opinion in Endocrinology & Diabetes and Obesity, vol. 21, no. 5, pp. 313–322, 2014. View at Publisher · View at Google Scholar
  • Vijaya Surampudi, and Ronald S. Swerdloff, “Testosterone replacement therapy: The controversies of cardiovascular risk,” Cardiovascular Endocrinology, vol. 4, no. 3, pp. 90–94, 2015. View at Publisher · View at Google Scholar
  • Jonathan R. S. Arch, “Horizons in the Pharmacotherapy of Obesity,” Current Obesity Reports, 2015. View at Publisher · View at Google Scholar
  • Neil Goodman, Andre Guay, Paresh Dandona, Sandeep Dhindsa, Charles Faiman, and Glenn R. Cunningham, “American Association Of Clinical Endocrinologists And American College Of Endocrinology Position Statement On The Association Of Testosterone And Cardiovascular Risk,” Endocrine Practice, vol. 21, no. 9, pp. 1066–1073, 2015. View at Publisher · View at Google Scholar
  • Shawn Riser Taylor, Lindsy M. Meadowcraft, and Bobbie Williamson, “Prevalence, Pathophysiology, and Management of Androgen Deficiency in Men with Metabolic Syndrome, Type 2 Diabetes Mellitus, or Both,” Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, vol. 35, no. 8, pp. 780–792, 2015. View at Publisher · View at Google Scholar
  • F Saad, A Yassin, G Doros, and A Haider, “Effects of long-term treatment with testosterone on weight and waist size in 411 hypogonadal men with obesity classes I-III: observational data from two registry studies,” International Journal of Obesity, 2015. View at Publisher · View at Google Scholar
  • Farid Saad, Aksam Yassin, Yousef Almehmadi, Gheorghe Doros, and Louis Gooren, “Effects of long-term testosterone replacement therapy, with a temporary intermission, on glycemic control of nine hypogonadal men with type 1 diabetes mellitus – a series of case reports,” The Aging Male, pp. 1–5, 2015. View at Publisher · View at Google Scholar
  • Dhananjay Vaidya, Sherita H. Golden, Nowreen Haq, Susan R. Heckbert, Kiang Liu, and Pamela Ouyang, “Association of sex hormones with carotid artery distensibility in men and postmenopausal women: Multi-ethnic study of atherosclerosis,” Hypertension, vol. 65, no. 5, pp. 1020–1025, 2015. View at Publisher · View at Google Scholar
  • D. M. Kelly, and T. H. Jones, “Testosterone and obesity,” Obesity Reviews, 2015. View at Publisher · View at Google Scholar
  • Роман Викторович Роживанов, and Юлия Николаевна Яшина, “Aspects of androgen replacement therapy for the treatment of hypogonadism in men with diabetes and metabolic syndrome.,” Obesity and metabolism, vol. 12, no. 1, pp. 11, 2015. View at Publisher · View at Google Scholar
  • Sartaj S. Hans, Sandeep S. Dhindsa, and Rama Chemitiganti, “Testosterone replacement and cardiovascular safety: No straight and narrow!,” Clinical Medicine Insights: Cardiology, vol. 9, pp. 33–37, 2015. View at Publisher · View at Google Scholar
  • Glenn R. Cunningham, “Testosterone and metabolic syndrome,” Asian Journal Of Andrology, vol. 17, no. 2, pp. 192–196, 2015. View at Publisher · View at Google Scholar
  • Michał Rabijewski, Lucyna Papierska, and Paweł Piątkiewicz, “Late-onset hypogonadism among old and middle-aged males with prediabetes in Polish population,” The Aging Male, pp. 1–6, 2015. View at Publisher · View at Google Scholar
  • Bruno Lunenfeld, George Mskhalaya, Michael Zitzmann, Stefan Arver, Svetlana Kalinchenko, Yuliya Tishova, and Abraham Morgentaler, “Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men,” The Aging Male, pp. 1–11, 2015. View at Publisher · View at Google Scholar
  • Giovanni Corona, Vito A Giagulli, Elisa Maseroli, Linda Vignozzi, Antonio Aversa, Michael Zitzmann, Farid Saad, Edoardo Mannucci, and Mario Maggi, “THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: results from a meta-analysis study,” European Journal of Endocrinology, vol. 174, no. 3, pp. R99–R116, 2015. View at Publisher · View at Google Scholar
  • Sandeep Dhindsa, Husam Ghanim, Manav Batra, Nitesh D. Kuhadiya, Sanaa Abuaysheh, Sartaj Sandhu, Kelly Green, Antoine Makdissi, Jeanne Hejna, Ajay Chaudhuri, Mark Punyanitya, and Paresh Dandona, “Insulin Resistance and Inflammation in Hypogonadotropic Hypogonadism and Their Reduction After Testosterone Replacement in Men With Type 2 Diabetes,” Diabetes Care, vol. 39, no. 1, pp. 82–91, 2015. View at Publisher · View at Google Scholar
  • Louis Gooren, “Diagnosing hypogonadism and treating decisions in different parts of the world: shifts in patterns between 2006 and 2015,” The Aging Male, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Abdulmaged M. Traish, and Michael Zitzmann, “The complex and multifactorial relationship between testosterone deficiency (TD), obesity and vascular disease,” Reviews in Endocrine and Metabolic Disorders, 2015. View at Publisher · View at Google Scholar
  • G. I. Hackett, “Testosterone Replacement Therapy and Mortality in Older Men,” Drug Safety, 2015. View at Publisher · View at Google Scholar
  • Michał Rabijewski, Lucyna Papierska, Roman Kuczerowski, and Paweł Piątkiewicz, “Hormonal determinants of erectile dysfunction and lower urinary tract symptoms in middle-aged and elderly men with prediabetes,” The Aging Male, pp. 1–9, 2015. View at Publisher · View at Google Scholar
  • Farid Saad, “The emancipation of testosterone from niche hormone to multi-system player,” Asian Journal Of Andrology, vol. 17, no. 1, pp. 58–60, 2015. View at Publisher · View at Google Scholar
  • Abraham Morgentaler, “Testosterone deficiency and cardiovascular mortality,” Asian Journal of Andrology, vol. 17, no. 1, pp. 26–31, 2015. View at Publisher · View at Google Scholar
  • Andrea Lenzi, Silvia Migliaccio, and Lorenzo Maria Doninipp. 1–350, 2015. View at Publisher · View at Google Scholar
  • Alessandro Ilacqua, Davide Francomano, and Antonio Aversapp. 99–106, 2015. View at Publisher · View at Google Scholar
  • Aksam Yassin, Yousef Almehmadi, Farid Saad, Gheorghe Doros, and Louis Gooren, “The Author's Reply: Changing testosterone had no direct effect on HbA1c or weight in diabetic men when TRT was interrupted and then resumed,” Clinical Endocrinology, vol. 85, no. 3, pp. 500–501, 2016. View at Publisher · View at Google Scholar
  • Geoffrey Hackett, “An update on the role of testosterone replacement therapy in the management of hypogonadism,” Therapeutic Advances in Urology, vol. 8, no. 2, pp. 147–160, 2016. View at Publisher · View at Google Scholar
  • G. Hackett, A. H. Heald, A. Sinclair, P. W. Jones, R. C. Strange, and S. Ramachandran, “Serum testosterone, testosterone replacement therapy and all-cause mortality in men with type 2 diabetes: retrospective consideration of the impact of PDE5 inhibitors and statins,” International Journal of Clinical Practice, vol. 70, no. 3, pp. 244–253, 2016. View at Publisher · View at Google Scholar
  • Marie-Astrid Denys, Ralf Anding, Andrea Tubaro, Paul Abrams, and Karel Everaert, “Lower urinary tract symptoms and metabolic disorders: ICI-RS 2014,” Neurourology and Urodynamics, vol. 35, no. 2, pp. 278–282, 2016. View at Publisher · View at Google Scholar
  • A. A. Yassin, J. Nettleship, Y. Almehmadi, M. Salman, and F. Saad, “Effects of continuous long-term testosterone therapy (TTh) on anthropometric, endocrine and metabolic parameters for up to 10 years in 115 hypogonadal elderly men: real-life experience from an observational registry study,” Andrologia, 2016. View at Publisher · View at Google Scholar
  • Hiroyuki Konaka, Kazuhiro Sugimoto, Hideki Orikasa, Teruaki Iwamoto, Toshinari Takamura, Yoshiyu Takeda, Kazuyoshi Shigehara, Masashi Iijima, Eitetsu Koh, and Mikio Namiki, “Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism: a multicenter, rand,” Asian Journal Of Andrology, vol. 18, no. 1, pp. 25–34, 2016. View at Publisher · View at Google Scholar
  • Tope A. Omololu, Adedunke T. Oludimu, Toluwalase Segun-Busari, Olakunle J. Onaolapo, Adejoke Y. Onaolapo, and Taofeeq Omoleke, “Exogenous testosterone, aging, and changes in behavioral response of gonadally intact male mice,” Journal of Experimental Neuroscience, vol. 2016, no. 10, pp. 59–70, 2016. View at Publisher · View at Google Scholar
  • Michał Rabijewski, Lucyna Papierska, and Paweł Piątkiewicz, “The Relationships between Anabolic Hormones and Body Composition in Middle-Aged and Elderly Men with Prediabetes: A Cross-Sectional Study,” Journal of Diabetes Research, vol. 2016, pp. 1–8, 2016. View at Publisher · View at Google Scholar
  • K.-S. Zhang, M.-J. Zhao, Q. An, Y.-F. Jia, L.-L. Fu, J.-F. Xu, and Y.-Q. Gu, “Effects of testosterone supplementation therapy on lipid metabolism in hypogonadal men with T2DM: a meta-analysis of randomized controlled trials,” Andrology, 2017. View at Publisher · View at Google Scholar
  • Ahmad Haider, Karim S Haider, and Farid Saad, “Remission of type 2 diabetes in a hypogonadal man under long-term testosterone therapy,” Endocrinology, Diabetes & Metabolism Case Reports, 2017. View at Publisher · View at Google Scholar
  • Jan Wolf, Dieter Keipert, Heiko Motazedi, Michael Ernst, Joanne Nettleship, and Louis Gooren, “Effectiveness and tolerability of parenteral testosterone undecanoate: a post-marketing surveillance study,” The Aging Male, pp. 1–10, 2017. View at Publisher · View at Google Scholar
  • Michał Rabijewski, Lucyna Papierska, and Paweł Piątkiewicz, “An association between bone mineral density and anabolic hormones in middle-aged and elderly men with prediabetes,” Aging Male, vol. 20, no. 3, pp. 205–213, 2017. View at Publisher · View at Google Scholar
  • Galina Afanas'evna Melnichenko, Marina Vladimirovna Shestakova, Roman Viktorovich Rozhivanov, Anna Leont'evna Terehova, Alexey Vadimovich Zilov, Daria Olegovna Ladygina, and Dmitriy Gennad'evich Kurbatov, “Guidelines for the diagnosis and treatment of testosterone deficiency (hypogonadism) in male patients with diabetes mellitus (Draft),” Diabetes mellitus, vol. 20, no. 2, pp. 151–160, 2017. View at Publisher · View at Google Scholar
  • Prita R. Asih, Michelle L. Tegg, Hamid Sohrabi, Malcolm Carruthers, Samuel E. Gandy, Farid Saad, Giuseppe Verdile, Lars M. Ittner, and Ralph N. Martins, “Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer’s Disease: Testosterone as a Modifier,” Journal of Alzheimer's Disease, pp. 1–22, 2017. View at Publisher · View at Google Scholar
  • Lina Schiffer, Punith Kempegowda, Wiebke Arlt, and Michael W O’Reilly, “MECHANISMS IN ENDOCRINOLOGY: The sexually dimorphic role of androgens in human metabolic disease,” European Journal of Endocrinology, vol. 177, no. 3, pp. R125–R143, 2017. View at Publisher · View at Google Scholar
  • Apostolos Apostolidis, Angie Rantell, Ralf Anding, Ruth Kirschner-Hermanns, and Linda Cardozo, “How does lower urinary tract dysfunction (LUTD) affect sexual function in men and women? ICI-RS 2015-Part 2,” Neurourology and Urodynamics, vol. 36, no. 4, pp. 869–875, 2017. View at Publisher · View at Google Scholar
  • Chon-Wai Jeremy Chan, Alain Veilleux, Mohamed Fouad Mansour, Sofia Laforest, and André Tchernofpp. 257–300, 2017. View at Publisher · View at Google Scholar
  • James Anaissie, Natalie H. Roberts, Ping Wang, and Faysal A. Yafi, “Testosterone Replacement Therapy and Components of the Metabolic Syndrome,” Sexual Medicine Reviews, 2017. View at Publisher · View at Google Scholar
  • Abdulmaged M. Traish, Ahmad Haider, Karim Sultan Haider, Gheorghe Doros, and Farid Saad, “Long-Term Testosterone Therapy Improves Cardiometabolic Function and Reduces Risk of Cardiovascular Disease in Men with Hypogonadism,” Journal of Cardiovascular Pharmacology and Therapeutics, pp. 107424841769113, 2017. View at Publisher · View at Google Scholar
  • Ivan I Dedov, Galina A Mel'nichenko, Marina V Shestakova, Roman V Rozhivanov, Anna L Terehova, Alexey V Zilov, Daria O Ladygina, and Dmitriy G Kurbatov, “Guidelines for the Diagnosis and Treatment of testosterone deficiency (hypogonadism) in male patients with diabetes mellitus,” Obesity and metabolism, vol. 14, no. 4, pp. 83–92, 2017. View at Publisher · View at Google Scholar
  • Geoff Hackett, Michael Kirby, David Edwards, Thomas Hugh Jones, Kevan Wylie, Nick Ossei-Gerning, Janine David, and Asif Muneer, “British Society for Sexual Medicine Guidelines on Adult Testosterone Deficiency, With Statements for UK Practice,” The Journal of Sexual Medicine, vol. 14, no. 12, pp. 1504–1523, 2017. View at Publisher · View at Google Scholar
  • Abdulmaged M. Traish, “Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men,” Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity, vol. 1043, pp. 473–526, 2017. View at Publisher · View at Google Scholar
  • Farid Saad, “Testosterone Therapy and Glucose Homeostasis in Men with Testosterone Deficiency (Hypogonadism),” Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity, vol. 1043, pp. 527–558, 2017. View at Publisher · View at Google Scholar
  • I. M. Antonyan, and V. N. Lеsovоy, “Efficiency and Safety of Bone Marrow Stem Cells for Androgen Deficiency Correction in Diabetes Mellitus Patients,” Ukraïnsʹkij žurnal medicini, bìologìï ta sportu, vol. 2, no. 6, pp. 56–62, 2017. View at Publisher · View at Google Scholar
  • Mahmoud Salman, Dany-Jan Yassin, Huda Shoukfeh, Joanne Elisabeth Nettleship, and Aksam Yassin, “Early weight loss predicts the reduction of obesity in men with erectile dysfunction and hypogonadism undergoing long-term testosterone replacement therapy,” The Aging Male, pp. 1–4, 2017. View at Publisher · View at Google Scholar
  • Allan Mazur, and Soazig Clifton, “Enzyme immunoassay may be inadequate for measuring salivary testosterone in older men,” The Aging Male, pp. 1–9, 2018. View at Publisher · View at Google Scholar
  • André Tchernof, Dannick Brochu, Ina Maltais-Payette, Mohamed Fouad Mansour, Geneviève B. Marchand, Anne-Marie Carreau, and Jordanna KapelutoComprehensive Physiology, pp. 1253–1290, 2018. View at Publisher · View at Google Scholar
  • L. Y. Morgunov, I. A. Denisova, T. I. Rozhkova, L. V. Stakhovskaya, and V. I. Skvortsova, “Hypogonadism and its treatment following ischaemic stroke in men with type 2 diabetes mellitus,” The Aging Male, pp. 1–10, 2018. View at Publisher · View at Google Scholar
  • Richard Bebb, Adam Millar, and Gerald Brock, “Sexual Dysfunction and Hypogonadism in Men With Diabetes,” Canadian Journal of Diabetes, vol. 42, pp. S228–S233, 2018. View at Publisher · View at Google Scholar
  • V. E. Bianchi, and V. Locatelli, “Testosterone a key factor in gender related metabolic syndrome,” Obesity Reviews, 2018. View at Publisher · View at Google Scholar
  • Sidika E. Karakas, and Prasanth Surampudi, “New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men,” vol. 86, pp. 71–125, 2018. View at Publisher · View at Google Scholar