Effects of Long-Term Testosterone Therapy on Patients with “Diabesity”: Results of Observational Studies of Pooled Analyses in Obese Hypogonadal Men with Type 2 Diabetes

Table 1

Baseline characteristics and measures at the end of the observation period for 156 obese hypogonadal men with type 2 diabetes mellitus treated with testosterone undecanoate for up to 6 years.

	Baseline	Endpoint
Mean age (years)	61.17±6.18
Anthropometry
Weight (kg)	113.56±11.53	97.18±9.05
BMI (kg/m^2)	36.31±3.51	31.19±2.6
Normal weight (proportion)	0	1 (0.6%)
Overweight (proportion)	0	48 (30.8%)
Obese (proportion)	156 (100%)	107 (68.6%)
Waist circumference (cm)	114.0±8.69	102.52±7.93
Normal (<94 cm)	1 (0.6%)	7 (4.5%)
Increased (≥ 94 cm)	155 (99.4%)	149 (95.5%)
Diabetic parameters
Fasting glucose (mg/dL)	128.37±31.63	101.55±17.02
Fasting glucose (mmol/L)	7.06±1.74	5.59±0.94
HbA1c	8.08±0.9	6.14±0.71
Other metabolic parameters
Total cholesterol (mg/dL)	294.85±47.65	194.38±16.79
Total cholesterol (mmol/L)	7.64±1.23	5.03±0.43
HDL cholesterol (mg/dL)	56.63±19.8	67.88±17.34
HDL cholesterol (mmol/L)	1.47±0.51	1.76±0.45
LDL cholesterol (mg/dL)	177.84±28.34	125.47±33.05
LDL cholesterol (mmol/L)	4.61±0.73	3.25±0.86
Triglycerides (mg/dL)	297.05±71.25	197.9±23.24
Triglycerides (mmol/L)	3.36±0.81	2.24±0.26
Systolic blood pressure (mmHg)	157.03±15.46	134.61±10.21
Diastolic blood pressure (mmHg)	93.89±11.67	79.0±5.57
Pulse pressure	63.07±10.7	55.61±8.62
Total cholesterol : HDL ratio	6.02±2.97	3.05±0.78
LDL : HDL ratio	3.61±1.71	1.88±0.41
CRP (mg/dL)	3.16±4.12	0.72±0.56
Liver enzymes
AST	35.55±13.28	23.94±8.77
ALT	39.04±19.38	26.08±14.42
Testosterone
Testosterone (nmol/L)	8.9±1.99	17.36±1.92