Influence of Vitamin D Binding Protein on Accuracy of 25-Hydroxyvitamin D Measurement Using the ADVIA Centaur Vitamin D Total Assay

Table 1

Serum concentrations of vitamin D binding protein in healthy subjects, DBP-spiked samples from healthy subjects, pregnant women, and dialysis patients.

	Number of samples	Average ± SD (μg/mL)	Range (μg/mL)	Median (μg/mL)	Interquartile (IQ) range (μg/mL)
Healthy not spiked (endogenous)	5	348 ± 106	261–519	ND	ND
Healthy (endogenous and endogenous + spiked)	30	512 ± 188^a	261–981	ND	ND
Healthy (endogenous + spiked)	25	545 ± 185^a	261–981	ND	ND
Pregnancy	36	415 ± 245^a	82–875	515	150–599
Dialysis	40	198 ± 173	63–1116	142	100–262

aP < 0.0001 compared to the dialysis group.
ND: not determined.
DBP: vitamin D binding protein.