Glucose Intolerance after a Recent History of Gestational Diabetes

Table 3

Comparison of the beta-cell function and insulin sensitivity between women with a normal OGTT and women with glucose intolerance/diabetes postpartum.

	Normal	Glucose intolerance/diabetes	value	Adjusted value
pISSI-2 mean	1.7 ± 0.4	1.5 ± 0.5	0.002	0.029
pMatsuda (median)	2.9 (2.0–4.1)	2.7 (1.7–3.7)	0.273	0.355
p1/HOMA-IR (median)	0.02 (0.01–0.03)	0.02 (0.01–0.03)	0.204	0.641
dISSI-2 (median)	2.2 (1.8–2.6)	1.5 (1.2–1.9)	<0.0001	0.020
dInsulinogenic index/HOMA-IR (median)	0.013 (0.010–0.019)	0.008 (0.005–0.014)	<0.0001	0.479
dMatsuda (median)	6.0 (4.3–8.8)	3.8 (2.6–6.2)	<0.0001	0.021
d1/HOMA-IR (median)	0.036 (0.027–0.056)	0.026 (0.018–0.052)	0.013	0.901

Only women with complete data on glucose and insulin levels were included in the analysis. pISSI-2: insulin secretion sensitivity index during pregnancy; pMatsuda: insulin sensitivity index of Matsuda during pregnancy; p1/HOMA-IR: the reciprocal of the homeostasis model assessment of insulin resistance during pregnancy; dISSI-2: insulin secretion sensitivity index postpartum; dMatsuda: insulin sensitivity index of Matsuda postpartum; dInsulinogenic index/HOMA-IR is a measure for beta-cell function postpartum; d1/HOMA-IR: the reciprocal of the homeostasis model assessment of insulin resistance postpartum; the values for the measurements during pregnancy are adjusted for age, BMI, ethnic background, multiparity, and corticoid treatment; the values for the measurements postpartum are adjusted for age, BMI, ethnic background, breastfeeding, and the progestin-only oral contraceptive.