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International Journal of Endocrinology
Volume 2014, Article ID 730472, 8 pages
Research Article

Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population

1Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, P.O. Box 1180, Kuwait City, Kuwait
2Diabetes Research Center, Qatar Biomedical Research Institute, P.O. Box 5825, Doha, Qatar
3Biostatistics and Epidemiology Department, Dasman Diabetes Institute, P.O. Box 1180, Kuwait City, Kuwait
4Dasman Diabetes Institute, P.O. Box 1180, Kuwait City, Kuwait
5Clinical Epidemiology, Sidra Medical and Research Center, P.O. Box 26999, Doha, Qatar

Received 7 July 2014; Accepted 26 August 2014; Published 9 September 2014

Academic Editor: Mario Maggi

Copyright © 2014 Mohamed Abu-Farha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ghrelin is a stomach produced hormone that has been shown to have protective role against development of CVD which is a leading cause of death in the Arab world. The objective of this study is to examine the gender difference in association between traditional CVD risk factors and plasma ghrelin among Arabs. 359 Arab residents in Kuwait participated in a cross-sectional survey (≥20 years old): 191 were females and 168 were males. Plasma level of ghrelin was assessed using Luminex-based assay. Ghrelin levels were significantly higher in females (935 ± 78 pg/mL) than males (763 ± 65 pg/mL) (). Females showed inverse association with WC (, ) and HbA1C (, ) as well as SBP (, ) and DBP (, ), respectively. Higher levels of ghrelin were shown to associate with increased insulin resistance, as measured by HOMAIR, in male Arab subjects (-trend = 0.0202) but not in females. In this study we show that higher ghrelin level was negatively associated with measures of obesity, HbA1C, and blood pressure in females and positively associated with increased insulin resistance in Arab males.