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International Journal of Endocrinology
Volume 2014, Article ID 730472, 8 pages
http://dx.doi.org/10.1155/2014/730472
Research Article

Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population

1Biochemistry and Molecular Biology Unit, Dasman Diabetes Institute, P.O. Box 1180, Kuwait City, Kuwait
2Diabetes Research Center, Qatar Biomedical Research Institute, P.O. Box 5825, Doha, Qatar
3Biostatistics and Epidemiology Department, Dasman Diabetes Institute, P.O. Box 1180, Kuwait City, Kuwait
4Dasman Diabetes Institute, P.O. Box 1180, Kuwait City, Kuwait
5Clinical Epidemiology, Sidra Medical and Research Center, P.O. Box 26999, Doha, Qatar

Received 7 July 2014; Accepted 26 August 2014; Published 9 September 2014

Academic Editor: Mario Maggi

Copyright © 2014 Mohamed Abu-Farha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. I. Koleva, M. M. Orbetzova, and P. K. Atanassova, “Adipose tissue hormones and appetite and body weight regulators in insulin resistance,” Folia Medica, vol. 55, no. 1, pp. 25–32, 2013. View at Google Scholar · View at Scopus
  2. A. Laviano, A. Molfino, S. Rianda, and F. Rossi Fanelli, “The growth hormone secretagogue receptor (GHs-R),” Current Pharmaceutical Design, vol. 18, no. 31, pp. 4749–4754, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. O. Ukkola, “Ghrelin in type 2 diabetes mellitus and metabolic syndrome,” Molecular and Cellular Endocrinology, vol. 340, no. 1, pp. 26–28, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. I. Kishimoto, T. Tokudome, H. Hosoda, M. Miyazato, and K. Kangawa, “Ghrelin and cardiovascular diseases,” Journal of Cardiology, vol. 59, no. 1, pp. 8–13, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Isgaard and R. Granata, “Ghrelin in cardiovascular disease and atherogenesis,” Molecular and Cellular Endocrinology, vol. 340, no. 1, pp. 59–64, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Scerif, A. P. Goldstone, and M. Korbonits, “Ghrelin in obesity and endocrine diseases,” Molecular and Cellular Endocrinology, vol. 340, no. 1, pp. 15–25, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Tesauro, F. Schinzari, M. Caramanti, R. Lauro, and C. Cardillo, “Metabolic and cardiovascular effects of ghrelin,” International Journal of Peptides, vol. 2010, Article ID 864342, 7 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. A. S. Go, D. Mozaffarian, V. L. Roger, E. J. Benjamin, and J. D. Berry, “Heart disease and stroke statistics—2013 update: a report from the American Heart Association,” Circulation, vol. 127, pp. e6–e245, 2013. View at Google Scholar
  9. H. S. Mattu and H. S. Randeva, “Role of adipokines in cardiovascular disease,” Journal of Endocrinology, vol. 216, no. 1, pp. T17–T36, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. V. Regitz-Zagrosek, E. Lehmkuhl, and M. O. Weickert, “Gender differences in the metabolic syndrome and their role for cardiovascular disease,” Clinical Research in Cardiology, vol. 95, pp. 136–147, 2006. View at Google Scholar
  11. J. Makovey, V. Naganathan, M. Seibel, and P. Sambrook, “Gender differences in plasma ghrelin and its relations to body composition and bone—an opposite-sex twin study,” Clinical Endocrinology, vol. 66, no. 4, pp. 530–537, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Hajat, O. Harrison, and Z. Al Siksek, “Weqaya: A population-wide cardiovascular screening program in Abu Dhabi, United Arab Emirates,” The American Journal of Public Health, vol. 102, no. 5, pp. 909–914, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Elkum, M. Al-Arouj, M. Sharifi, K. Behbehani, and A. Bennakhi, “Cardiovascular disease risk factors in the South Asian population living in Kuwait: a cross-sectional study,” Diabetic Medicine, vol. 31, no. 5, pp. 531–539, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Abu-Farha, K. Behbehani, and N. Elkum, “Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs,” Cardiovascular Diabetology, vol. 13, article 76, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Stepień, K. Rosniak-Bak, M. Paradowski et al., “Waist circumference, ghrelin and selected adipose tissue-derived adipokines as predictors of insulin resistance in obese patients: preliminary results,” Medical Science Monitor, vol. 17, no. 11, pp. PR13–PR18, 2011. View at Google Scholar · View at Scopus
  16. P. J. D. Delhanty and A. J. van der Lely, “Ghrelin and glucose homeostasis,” Peptides, vol. 32, no. 11, pp. 2309–2318, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. L. P. Shearman, S.-P. Wang, S. Helmling et al., “Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice,” Endocrinology, vol. 147, no. 3, pp. 1517–1526, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. D. E. Cummings, D. S. Weigle, R. Scott Frayo et al., “Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery,” The New England Journal of Medicine, vol. 346, no. 21, pp. 1623–1630, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. M. M. Scott, M. Perello, J.-C. Chuang et al., “Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose,” PLoS ONE, vol. 7, no. 8, Article ID e44089, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Pradhan, S. L. Samson, and Y. Sun, “Ghrelin: much more than a hunger hormone,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 16, no. 6, pp. 619–624, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. X. Yin, Y. Li, G. Xu, W. An, and W. Zhang, “Ghrelin fluctuation, what determines its production?” Acta Biochimica et Biophysica Sinica, vol. 41, no. 3, pp. 188–197, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Kojima and K. Kangawa, “Ghrelin: structure and function,” Physiological Reviews, vol. 85, no. 2, pp. 495–522, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Pacifico, E. Poggiogalle, F. Costantino et al., “Acylated and nonacylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome,” European Journal of Endocrinology, vol. 161, no. 6, pp. 861–870, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. T. McLaughlin, F. Abbasi, C. Lamendola, R. S. Frayo, and D. E. Cummings, “Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive contrls,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 4, pp. 1630–1635, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Zhao, L. Shao, L. Teng, D. Zhang, and H. Zhang, “Relationship between plasma ghrelin levels and insulin resistance and blood pressure in octogenarians,” Journal of Huazhong University of Science and Technology—Medical Science, vol. 30, no. 3, pp. 307–311, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. P. Amini, D. Wadden, F. Cahill et al., “Serum acylated ghrelin is negatively correlated with the insulin resistance in the CODING study,” PLoS ONE, vol. 7, no. 9, Article ID e45657, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. K. M. Heppner, C. L. Piechowski, A. Müller et al., “Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors,” Diabetes, vol. 63, no. 1, pp. 122–131, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Pöykkö, O. Ukkola, H. Kauma, M. J. Savolainen, and Y. A. Kesäniemi, “Ghrelin Arg51Gln mutation is a risk factor for Type 2 diabetes and hypertension in a random sample of middle-aged subjects,” Diabetologia, vol. 46, no. 4, pp. 455–458, 2003. View at Google Scholar · View at Scopus
  29. C. Schöfl, R. Horn, T. Schill, H. W. Schlösser, M. J. Müller, and G. Brabant, “Circulating ghrelin levels in patients with polycystic ovary syndrome,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 10, pp. 4607–4610, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. P. J. Delhanty, S. J. Neggers, and A. J. van der Lely, “Mechanisms in endocrinology: ghrelin: the differences between acyl- and des-acyl ghrelin,” European Journal of Endocrinology, vol. 167, no. 5, pp. 601–608, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. J. N. Freeman, J. M. D. Carmo, A. H. Adi, and A. A. da Silva, “Chronic central ghrelin infusion reduces blood pressure and heart rate despite increasing appetite and promoting weight gain in normotensive and hypertensive rats,” Peptides, vol. 42, pp. 35–42, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Hlebowicz, S. Lindstedt, O. Björgell, and M. Dencker, “The effect of endogenously released glucose, insulin, glucagon-like peptide 1, ghrelin on cardiac output, heart rate, stroke volume, and blood pressure,” Cardiovascular Ultrasound, vol. 9, no. 1, article 43, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Mizia-Stec, B. Zahorska-Markiewicz, M. Olszanecka-Glinianowicz et al., “Ghrelin as a potential blood pressure reducing factor in obese women during weight loss treatment,” Endokrynologia Polska, vol. 59, no. 3, pp. 207–211, 2008. View at Google Scholar · View at Scopus
  34. A. Rodríguez, J. Gómez-Ambrosi, V. Catalán et al., “Association of plasma acylated ghrelin with blood pressure and left ventricular mass in patients with metabolic syndrome,” Journal of Hypertension, vol. 28, no. 3, pp. 560–567, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. N. Nagaya, M. Kojima, M. Uematsu et al., “Hemodynamic and hormonal effects of human ghrelin in healthy volunteers,” American Journal of Physiology: Regulatory Integrative and Comparative Physiology, vol. 280, no. 5, pp. R1483–R1487, 2001. View at Google Scholar · View at Scopus
  36. Y. Makino, H. Hosoda, K. Shibata et al., “Alteration of plasma ghrelin levels associated with the blood pressure in pregnancy,” Hypertension, vol. 39, no. 3, pp. 781–784, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. Z.-F. Li, D.-X. Zhou, W.-Z. Pan, L. Zhang, and J.-B. Ge, “Circulating ghrelin was negatively correlated with pulmonary arterial pressure in atrial septal defect patients,” Chinese Medical Journal, vol. 126, no. 20, pp. 3936–3939, 2013. View at Publisher · View at Google Scholar · View at Scopus