Primary Thyroid Disorders in Patients with Endogenous Hypercortisolism: An Observational Study

Table 1

Thyroid function tests and autoantibody panel of the patients with Cushing’s syndrome and control subjects. Group 1A corresponds to the patients before cure whereas Group 1B includes the patients after cure for Cushing’s syndrome. Group 2 is the control group.

	Group 1A (𝑛=40)	Group 1B (𝑛=25)	Group 2 (𝑛=40)	(𝑃) Group 1A versus 2	(𝑃) Group 1B versus 2	(𝑃) Group 1A versus 1B
Serum TSH	1.3 ± 1.2	1.6 ± 1.2	2.2 ± 1.3	<0.01	0.06	0.223
Serum fT3	3.1 ± 0.8	3 ± 0.8	3.4 ± 0.7	0.09	0.035	0.814
Serum fT4	1.2 ± 0.3	1.2 ± 0.4	1.3 ± 0.2	0.4	0.442	0.646
Anti-Tg positivity (%)	4 (10)	4 (16)	3 (7.5)	0.692	0.253	0.371
Anti-TPO positivity (%)	4 (10)	5 (20)	5 (12.5)	0.723	0.322	0.221
Antibody positivity (%)^a	6 (15)	7 (28)	7 (17.5)	0.762	0.244	0.169

TSH: thyroid stimulating hormone; fT3: free triiodothyronine; fT4: free thyroxine; anti-Tg: antithyroglobulin antibody; anti-TPO: antithyroperoxidase antibody. Statistical significance was set at a 𝑃 value of 5%. Numerical data was expressed as mean ± SD. Normal values: fT3: 1.8–4.6 pg/mL, fT4: 0.9–1.7 ng/dL, and TSH: 0.27–4.2 uIU/mL. ^aPositivity of anti-Tg and/or anti-TPO.
Data on thyroid function tests (TFTs) and autoantibody panel were evaluated 6 months after curative surgery.