MicroRNA Deregulation in Anaplastic Thyroid Cancer Biology

Figure 2

Some miRNAs act as oncomiRs. Deregulation of miRNA changes physiological protein level balances and enhances the oncogenic process where (1) low expression of an miRNA may enhance protein translation of an oncogenic protein or (2) high expression of an miRNA may repress the translation of a tumor suppressor gene. Both situations may occur concomitantly in cancer as observed in anaplastic thyroid cancer.