MicroRNA Deregulation in Anaplastic Thyroid Cancer Biology

Table 1

Validated targets for deregulated miRNAs in ATC.

miRNAs		Validated targets			Cellular processes	References
Downregulated miRs	miR-200 family	ZEB1	ZEB2	β-Catenin	EMT and proliferation	[21, 67]
	miR-30 family	Beclin1	EZH2	VIM	Autophagy, chromatin condensation, and EMT	[30, 33, 67]
	let-7 family	RAS	HMGA2	LIN28	Proliferation, histone modification, and stemness	[67, 68]
	miR-25	EZH2	BIM	KLF4	Chromatin condensation and apoptosis	[30, 67]
	miR-125	MMP1	HMGA2	LIN28A	Invasion, histone modification, and stemness	[20, 67, 69]
Upregulated miRs	miR-221/miR-222	p27	RECK	PTEN	Cell cycle, growth, and invasion	[20, 67]
	miR-17-92 cluster	p21	TIMP3	PTEN	Cell growth and invasion	[45, 67]
	miR-146a/miR-146b	NFκB	THRB	SMAD4	Cell differentiation, proliferation, and invasion	[52, 67, 70, 71]