Review Article
Update on Anaplastic Thyroid Carcinoma: Morphological, Molecular, and Genetic Features of the Most Aggressive Thyroid Cancer
Table 3
Immunohistochemical features of ATCs.
| Immunostain | Percentage of positive cases |
| Cytokeratin | 40–100% | Vimentin | 100% (in spindle cells) | EMA | 30–50% (in squamoid cells) | CEA | Rarely (in squamoid cells) | Thyroglobulin | 0% (false positivity due to nonneoplastic thyroid follicular cells entrapped in the tumor or diffusion from destroyed normal follicles) | TTF-1 | 0% | RET/PTC oncoprotein | 0% | Calcitonin | 0% | PAX8 | 0–79% of ATCs (probably depending on antibody used); 92% of ATCs with squamoid features |
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