Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice
Figure 4
Dietary intake of baicalein ameliorated hyperglycemia in STZ-induced obese diabetic mice. MaleC57BL/6 mice (8 mo old) were fed a HF diet containing 0, 0.25, and 0.5 g baicalein/kg diet for 4 wks prior to administration of STZ (40 mg/kg for 3 days) and continued on the same diet for 5 wks. Aged-matched mice were fed a SD diet. Nonfasting blood glucose and (a) body weight (b) were monitored every wk after injection of STZ. Plasma insulin levels (c) in fasted mice were measured by ELISA. Data are means ± SE ( mice/group). versus HF + STZ group, versus SD group. SD: standard diet, HF: high-fat diet, B1: 0.25 g baicalein/kg diet, and B2: 0.5 g baicalein/kg diet.
