Table 2: Second-generation antipsychotics and the risk of metabolic abnormalities [47, 49].

DrugWeight gainRisk for diabetes mellitusWorsening lipid profile

Clozapine+++++
Olanzapine+++++
Risperidone++DD
Quetiapine++DD
Aripiprazole*+/−
Ziprasidone*+/−

+: increase effect; −: no effect; D: discrepant results; newer drugs with limited data.