Autoimmune and Neoplastic Thyroid Diseases Associated with Hepatitis C Chronic Infection

Figure 1

HCV thyroid infection may act by upregulating CXCL10 gene expression and secretion in thyrocytes recruiting Th1 lymphocytes that secrete IFN-γ and TNF-α. These cytokines induce CXCL10 secretion by thyrocytes, thus perpetuating the immune cascade.