Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan
Glucose and insulin homeostasis during OGTT in the normal glucose-tolerant subjects according to genotypes of the KCNJ11 gene. There was no significant difference in plasma glucose levels in subjects with EE genotype compared with those with K23-allele-containing genotypes (EK or KK) (a). Subjects with EK/KK genotypes tended to have a higher level of plasma insulin level during OGTT (b). * indicates significant difference between the two groups.