Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan
Table 3
Logistic regression analysis with type 2 diabetic status as dependent variables, age, sex, BMI age- and sex-specific percentiles, and genotype of E23K polymorphism in Kir6.2 as independent variables.
Independent variables
Odds ratio
95% CI
value
Model 1
EK/KK versus EE
2.941
0.764–11.323
0.117
Age (every 1 year increment)
1.156
0.920–1.454
0.214
Sex (male = 1, female = 2)
0.672
0.224–2.019
0.479
BMI age- and sex-specific percentiles (every 1 percentile increment)
1.060
1.027–1.094
<0.001
Model 2
EK/KK versus EE
4.105
1.0008–16.831
0.047
Age (every 1 year increment)
1.240
0.960–1.601
0.099
Sex (male = 1, female = 2)
0.826
0.252–2.711
0.752
BMI age- and sex-specific percentiles (every 1 percentile increment)