International Journal of Endocrinology / 2014 / Article / Tab 4

Research Article

Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan

Table 4

Clinical and metabolic features between those with E/E genotype and K-containing allele among type 2 diabetic and nondiabetic subjects, respectively.

Type 2 diabetic subjectsNondiabetic subjects
GenotypesE/E ()E/K + K/K () value*E/E ()E/K + K/K () value*

Sex (M : F)4 : 216 : 160.663$11 : 1315 : 300.434$
Age (years)21.5 ± 9.718.0 ± 5.80.24217.2 ± 3.3 17.4 ± 4.10.861
BMI age- sex-specific percentiles84.02 ± 22.0783.73 ± 14.310.97056.65 ± 25.6356.79 ± 30.870.987
Glucose (mmol/L)10.0 ± 3.810.8 ± 4.10.7155.1 ± 0.45.2 ± 0.40.133
Fasting plasma insulin levels (pmol/L)237.21 ± 230.48112.18 ± 126.240.07652.2 ± 31.156.5 ± 32.80.602
Ins-30′414.67 ± 53.23582.09 ± 94.710.222
Ins-60′381.81 ± 51.51671.57 ± 132.390.046
Ins-90′379.09 ± 55.41545.79 ± 107.510.280
Ins-120′268.32 ± 48.95375.18 ± 67.100.283
AUC-glucose832.92 ± 21.83855.72 ± 17.020.422
AUC-insulin40074.46 ± 4153.7460457.87 ± 10721.200.180
HOMA-B127.0 ± 194.889.89 ± 1680.68597.69 ± 70.0392.98 ± 51.550.751

value with Student’s -test.
$ value with Fisher’s exact test.