Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β/AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling

Figure 2

Islets from DEX-treated rats are more responsive to glucose than islets from DEX-treated mice. ((a), (c)) Static cumulative insulin secretion in isolated islets from DEX-treated mice and rats in response to different glucose concentrations, respectively. ((b), (d)) Normalized glucose-stimulated insulin secretion (GSIS) (fold increase in relation to 2.8 mmol/L glucose) in mice and in rats, respectively. Values are mean ± S.E.M.; 4–6 wells from 5 different animals. Significantly different compared to CTL. Unpaired Student’s -test, .