Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β/AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling
Figure 4
DEX treatment increases β-cell proliferation without affecting apoptosis in the islets of mice and rats. (a) Representative pancreas sections stained for insulin (on the top) and KI-67 (at bottom), (b) percentage of KI-67-positive nuclei (+) β-cell, (c) PCNA content, (d) DNA fragmentation/total DNA (ratio), and (e) caspase-3 cleavage/total caspase-3 ratio in islets from DEX-treated mice and rats. Values are mean ± S.E.M.; 5-6 rodents per group; ≈100 islets per species (≈8500 nuclei per group). Significantly different compared to CTL. Unpaired Student’s -test, .
